Hulbert J
J Clin Pathol. 1972 Jan;25(1):73-5. doi: 10.1136/jcp.25.1.73.
The urinary excretion of three oral preparations of penicillin G was measured in six subjects. After a dose of 500 mg of potassium penicillin G the mean urine level was 597 mug/ml in the first of three two-hour periods, 324 mug/ml in the second, and 40 mug/ml between the fourth and sixth hours. Of the dose, 13.4% was excreted in the urine in 24 hours. Differences among the three preparations were not significant therapeutically. Most Gram-negative urinary pathogens are sensitive to 5-50 mug of penicillin G per ml. There is a rational basis for the use of oral penicillini G to treat urinary infection due to Gram-negative bacilli.
对6名受试者测定了三种青霉素G口服制剂的尿排泄情况。给予500mg青霉素G钾剂量后，在三个两小时时间段的第一个时间段，尿平均水平为597μg/ml，第二个时间段为324μg/ml，在第四至第六小时之间为40μg/ml。给药剂量的13.4%在24小时内从尿中排泄。三种制剂之间的差异在治疗上无显著意义。大多数革兰氏阴性尿路病原体对每毫升5 - 50μg的青霉素G敏感。使用口服青霉素G治疗革兰氏阴性杆菌引起的尿路感染有合理的依据。
