Ling G V, Conzelman G M, Franti C E, Ruby A L
Am J Vet Res. 1980 Jul;41(7):1123-5.
Penicillin G, penicillin V, ampicillin, hetacillin, and amoxicillin were administered separately per os to clinically normal adult dogs of both sexes at 8-hour intervals for five consecutive 8-hour test periods. All urine was collected from each dog during each test period and was assayed for antimicrobial activity. Daily doses of the antimicrobics used were as follows: penicillin G, 110,000 U/kg of body weight; penicillin V, 77 mg/kg; ampicillin, 77 mg/kg; hetacillin, 77 mg/kg; and amoxicillin, 33 mg/kg. Mean 8-hour urine concentrations (+/- 1 SD) were as follows: penicillin G, 294 +/- 210 U/ml; penicillin V, 148 +/- 98 micrograms/ml; ampicillin, 309 +/- 55 micrograms/ml; hetacillin, 300 +/- 156 micrograms/ml, and amoxicillin 201 +/- 93 micrograms/ml. Among the three antimicrobials administered at the same daily dosage, ie, penicillin V, ampicillin, and hetacillin, the mean urine concentrations of penicillin V were significantly lower (P < 0.01) than were concentrations of ampicillin and hetacillin. The mean urine concentrations of the latter two did not differ significantly (P > 0.05).
将青霉素G、青霉素V、氨苄西林、海他西林和阿莫西林分别以8小时间隔口服给予临床正常的成年雌雄犬，连续进行5个8小时的试验期。在每个试验期内收集每只犬的所有尿液，并检测其抗菌活性。所用抗菌药物的每日剂量如下：青霉素G，110,000 U/kg体重；青霉素V，77 mg/kg；氨苄西林，77 mg/kg；海他西林，77 mg/kg；阿莫西林，33 mg/kg。8小时尿液平均浓度（±1标准差）如下：青霉素G，294±210 U/ml；青霉素V，148±98μg/ml；氨苄西林，309±55μg/ml；海他西林，300±156μg/ml；阿莫西林，201±93μg/ml。在以相同每日剂量给药的三种抗菌药物中，即青霉素V、氨苄西林和海他西林，青霉素V的平均尿液浓度显著低于（P<0.01）氨苄西林和海他西林的浓度。后两者的平均尿液浓度无显著差异（P>0.05）。
