Brazier M A, Crandall P H, Brown W J
Electroencephalogr Clin Neurophysiol. 1975 May;38(5):495-506. doi: 10.1016/0013-4694(75)90190-x.
Four cases, given in some detail, illustrate the effort to compare scalp EEGs taken before surgery for intractable seizures with those recorded some years postoperatively, and to relate these, together with the computer analyses of seizure activity recorded in depth, with the pathology found in the removed tissue and, importantly, with the postoperative clinical state of the patient. These four cases illustrate the following results: (1) Confirmation by histology and ultrastructure studies of abnormal neuronal tissue at the site pinpointed by computer analysis of EEGs as the driving focus for the electrical seizure discharge. (2) Correlation of clinical and behavioral improvement with normalization of the EEG, objectively quantified by computer analysis. Examples are given of excellent recovery (3 cases) and one of, at present, partial recovery.
将顽固性癫痫手术前采集的头皮脑电图与术后数年记录的脑电图进行比较，并将这些脑电图与深度记录的癫痫活动的计算机分析结果，与切除组织中发现的病理情况，以及重要的是与患者的术后临床状态联系起来。这四个病例说明了以下结果：（1）组织学和超微结构研究证实，脑电图计算机分析确定为癫痫放电驱动灶的部位存在异常神经元组织。（2）临床和行为改善与脑电图正常化相关，脑电图正常化通过计算机分析进行客观量化。给出了良好恢复（3例）和目前部分恢复（1例）的例子。
