对类风湿性关节炎患者的血红素生物合成进行了研究。

Haem biosynthesis studied in patients with rheumatoid arthritis.

作者信息

Johansson S V, Strandberg P O

出版信息

J Clin Pathol. 1972 Feb;25(2):159-62. doi: 10.1136/jcp.25.2.159.

DOI:10.1136/jcp.25.2.159

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC477248/

Abstract

In a study of the urinary excretion of haem precursors in patients with rheumatoid arthritis, iron-deficiency anaemia, and in healthy controls, certain differences were found. In iron-deficiency anaemia the excretion of both porphobilinogen and delta-aminolevulinic acid was increased, whereas in patients with rheumatoid arthritis only the porphobilinogen excretion was increased.A further study on the erythrocyte activity of delta-aminolevulinic acid dehydrase showed a higher activity in the erythrocytes from patients with rheumatoid arthritis compared with healthy controls.

摘要

在一项关于类风湿性关节炎患者、缺铁性贫血患者及健康对照者血红素前体尿排泄的研究中，发现了某些差异。在缺铁性贫血中，胆色素原和δ-氨基-γ-酮戊酸的排泄均增加，而在类风湿性关节炎患者中，仅胆色素原排泄增加。另一项关于δ-氨基-γ-酮戊酸脱水酶红细胞活性的研究表明，与健康对照者相比，类风湿性关节炎患者红细胞中的该酶活性更高。

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Marrow iron examination in the diagnosis of iron deficiency in rheumatoid arthritis.骨髓铁检查在类风湿关节炎缺铁诊断中的应用

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Nature of anaemia in rheumatoid arthritis. III. Changes in the bone marrow and their relation to other features of the disease.类风湿关节炎中的贫血本质。III. 骨髓变化及其与疾病其他特征的关系。

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