Will J A, Bisgard G E
Thorax. 1972 Jan;27(1):120-6. doi: 10.1136/thx.27.1.120.
The haemodynamic effects of four daily oral doses of 1·5 mg/kg of aminorex (as fumarate) were measured in unanaesthetized beagle dogs. A similar study was performed in another group of related animals using d-amphetamine sulphate (1 mg/kg). Both agents produced similar sympathomimetic effects consisting of transient rises in systemic and pulmonary arterial blood pressures over an eight-hour period after administration of either drug. Heart rate remained unchanged in the dogs receiving aminorex whereas it decreased in those receiving amphetamine. There was no cumulative or residual haemodynamic effect of either drug. We therefore conclude that neither aminorex nor amphetamine readily produces sustained pulmonary hypertension in beagle dogs.
在未麻醉的比格犬中测量了每日口服4次、剂量为1.5mg/kg氨基苯丙醇（以富马酸盐形式）的血流动力学效应。在另一组相关动物中使用硫酸右苯丙胺（1mg/kg）进行了类似研究。两种药物都产生了类似的拟交感神经效应，即在给药后8小时内，体循环和肺动脉血压短暂升高。接受氨基苯丙醇的犬心率保持不变，而接受苯丙胺的犬心率下降。两种药物均无累积或残留的血流动力学效应。因此，我们得出结论，氨基苯丙醇和苯丙胺在比格犬中均不易引起持续性肺动脉高压。
