Mustafa K Y, Turunen U, Gumaa K A
J Trop Med Hyg. 1979 Jun;82(6):122-7.
Two areas of the Sudan known to be endemic to onchocerciasis were surveyed for skin and ocular changes, and serum vitamin A levels in patients and normal controls. In Southern Sudan severe eye lesions and blindness are common complications. In Northern Sudan skin lesions predominate, and no case of blindness was recorded. Serum vitamin A levels were found to be adequate in all groups studied. However, patients from Southern Sudan with both eye and skin lesions due to onchocerciasis had the lowest mean serum vitamin A level. The significance of these findings is discussed in relation to the possible aetiological role of vitamin A deficiency in the pathogenesis of ocular complications of onchocerciasis.
对苏丹已知盘尾丝虫病流行的两个地区进行了调查，以了解患者和正常对照者的皮肤和眼部变化以及血清维生素A水平。在苏丹南部，严重的眼部病变和失明是常见的并发症。在苏丹北部，皮肤病变占主导，未记录到失明病例。在所研究的所有组中，血清维生素A水平均充足。然而，苏丹南部因盘尾丝虫病导致眼部和皮肤病变的患者血清维生素A平均水平最低。结合维生素A缺乏在盘尾丝虫病眼部并发症发病机制中可能的病因学作用，对这些发现的意义进行了讨论。
