Nakata Y
Jpn Circ J. 1979 Aug;43(8):734-40. doi: 10.1253/jcj.43.734.
For the purpose of unraveling the relations between disturbances in microcirculation and deposition of lipids in the aortic wall, 9 rabbits were fed a 1% cholesterol and 5% coconut oil at intervals up to 16 weeks, and 4 rabbits were used as controls. After microangiography of vasa vasorum, the same specimens were studied histochemically. The distribution of vasa vasorum became poorer on sacrifice by microangiography. However, it could not be thought that disturbances in vasa vasorum was a cause in the early deposition of lipids, because lesions were histologically mild in the greater parts of vasa vasorum. The sites of prediction for the vascular lesions were initially the branching part, and then the thoracic aorta. Thickness and numbers of the elastic lamina in the media decreased straightly in the distal direction, and the degree of intimal thickening and accumulation of lipids were parallel with the degree of the medial thickness. The intimal cells tended to be arranged radially with wide intercellular spaces in the cross section, suggesting the convenience for the passage of fluids. From the above facts, it may be reasonable to presume that the difference in severity of disturbances of microcirculation resulted in the difference in the site of predilection.
为了阐明微循环紊乱与主动脉壁脂质沉积之间的关系，9只兔子每隔一段时间喂食1%胆固醇和5%椰子油，持续16周，4只兔子作为对照。在对滋养血管进行微血管造影后，对相同标本进行组织化学研究。通过微血管造影观察，在处死时滋养血管的分布变得更差。然而，不能认为滋养血管紊乱是脂质早期沉积的原因，因为在大部分滋养血管中组织学病变较轻。血管病变的好发部位最初是分支部位，然后是胸主动脉。中膜弹性膜的厚度和数量向远端直线减少，内膜增厚程度和脂质积聚程度与中膜厚度程度平行。在内膜横切面上，细胞倾向于呈放射状排列，细胞间隙较宽，这表明有利于液体通过。基于上述事实，推测微循环紊乱严重程度的差异导致好发部位的差异可能是合理的。
