Zérah L, Ammon J P, Bonnardot J P, Goussard D, Bunodière M, Deligné P
Ann Anesthesiol Fr. 1975 Dec;16(8):615-26.
This second electromyographic study of AH-8165, a product derived from azobis-arymilidazo-(1-2a) pyridinium, carried out with a special apparatus which both stimulates and records, specifies the characteristics of the neuro-muscular block induced by this new non-depolarizing type curarizing substance while taking into account the usual factors of the curarimimetic variability of action. After an initial dose of 1 mg per kg of bodyweight, we notice particularly: -the lapse of time required for a complete block (90 s), its intensity and duration (normally total during at least one hour) -the morphology of the electromyogram during the curarization and the decurarization either spontaneous or induced by Neostigmin with in particular -the muscular fatigability after repeated stimulation following curarization and chiefly during decurarization, chronological data und electro-myographic aspects which are found as well after a reinjection of AH-8165 equivalent to the half of the previous one.
这是对AH - 8165进行的第二项肌电图研究。AH - 8165是一种源自偶氮双芳基咪达唑 -（1 - 2a）吡啶鎓的产品，研究使用了一种既能刺激又能记录的特殊仪器，明确了这种新型非去极化型箭毒样物质所诱导的神经肌肉阻滞的特征，同时考虑到箭毒样作用变异性的常见因素。在给予每千克体重1毫克的初始剂量后，我们特别注意到： - 完全阻滞所需的时间间隔（90秒）、其强度和持续时间（通常至少一小时内完全阻滞） - 箭毒化和脱箭毒化过程中肌电图的形态，无论是自发的还是由新斯的明诱导的，特别是 - 箭毒化后重复刺激尤其是脱箭毒化期间的肌肉疲劳性，再次注射相当于前一次一半剂量的AH - 8165后也能观察到时间顺序数据和肌电图方面的情况。
