[Electromyography and AH/8165 in man].

This article concerns the electromyographical study of a synthetic curare derived from Azobis Arylimidazo (1-2a) Pyridinium (AH/8165) with a simultaneous recording of the spontaneous diaphragmatic activity and "testing" of the neuro-muscular transmission at the level of a peripheral muscle. This study shows that AH/8165 is a powerful non-depolirizing curarimimetic drug that quickly induces a neuro-muscular block at the level of the diaphragm and the peripheric muscles that can be reversed by anticholinesterasic drugs. Its reaction time is short (about 1 mn). There are importante individual variations in the duration of the neuromuscular blockage. Towards the end of the experience, tetanizing stimulations reveal a muscular fatigability in all the cases. No ill side-effects could be observed upon the cardiovascular system or any side-effects ascribable to a histaminergic mechanism.