Carlson J R, Yokoyama M T, Dickinson E O
Science. 1972 Apr 21;176(4032):298-9. doi: 10.1126/science.176.4032.298.
Microorganisms from rumen converted L-tryptophan and indoleacetic acid to 3-methylindole in vitro. Oral doses of 3-methylindole caused interstitial pulmonary edema and emphysema in cattle and goats. Intravenous infusion of this metabolite also induced pulmonary disease in cattle. These results demonstrate than an end product of ruminal fermentation of tryptophan can induce acute pulmonary disease in cattle and goats.
瘤胃中的微生物可在体外将L-色氨酸和吲哚乙酸转化为3-甲基吲哚。口服3-甲基吲哚会导致牛和山羊出现间质性肺水肿和肺气肿。静脉输注这种代谢产物也会在牛身上引发肺部疾病。这些结果表明，色氨酸瘤胃发酵的终产物可在牛和山羊身上诱发急性肺部疾病。
