毛果天芥菜碱、倒千里光碱和倒千里光裂碱吡咯对培养的人胚肺和肝细胞的作用。
The effects of lasiocarpine, retrorsine and retronecine pyrrole on human embryo lung and liver cells in culture.
作者信息
Armstrong S J, Zuckerman A J
出版信息
Br J Exp Pathol. 1972 Apr;53(2):138-44.
Abstract
Retronecine pyrrole induces toxic changes both in human liver and lung cells. Lasiocarpine and retrorsine are toxic to liver cells but not to lung cells, which are unable to metabolize the pyrrolizidine alkaloids to pyrroles. The application of lasiocarpine to human liver cells in culture is followed by inhibition of DNA, RNA and protein synthesis; vacuolation of the cells, the prevention of mitosis and the formation of giant cells (“megalocytes”).
摘要
倒千里光裂碱吡咯可在人肝细胞和肺细胞中诱导毒性变化。毛果天芥菜碱和倒千里光碱对肝细胞有毒性，但对肺细胞无毒，因为肺细胞无法将吡咯里西啶生物碱代谢为吡咯。在培养的人肝细胞中应用毛果天芥菜碱后，会抑制DNA、RNA和蛋白质合成；细胞出现空泡化，有丝分裂受到抑制，并形成巨细胞（“大细胞”）。
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