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Effects on atrioventricular conduction and blood flow of enantiomers of verapamil and of tetrodotoxin injected into the posterior and the anterior septal artery of the atrioventricular node preparation of the dog.

作者信息

Satoh K, Yanagisawa T, Taira N

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1979 Aug;308(2):89-98. doi: 10.1007/BF00499049.

DOI:10.1007/BF00499049
PMID:503249
Abstract
摘要

相似文献

1
Effects on atrioventricular conduction and blood flow of enantiomers of verapamil and of tetrodotoxin injected into the posterior and the anterior septal artery of the atrioventricular node preparation of the dog.
Naunyn Schmiedebergs Arch Pharmacol. 1979 Aug;308(2):89-98. doi: 10.1007/BF00499049.
2
Effects of neurotransmitters injected into the posterior and the anterior septal artery on the automaticity of the atrioventricular junctional area of the dog heart.注射到后间隔动脉和前间隔动脉中的神经递质对犬心脏房室交界区自律性的影响。
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3
Effects of atrio-ventricular conduction of calcium-antagonistic coronary vasodilators, local anaesthetics and quinidine injected into the posterior and the anterior septal artery of the atrio-ventricular node preparation of the dog.钙拮抗剂、局部麻醉药和奎尼丁注入犬房室结标本的后间隔动脉和前间隔动脉对房室传导的影响。
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4
Effects of nifedipine, a potent calcium-antagonistic coronary vasodilator, on atrioventricular conduction and blood flow in the isolated atrioventricular node preparation of the dog.强效钙拮抗型冠状动脉扩张剂硝苯地平对犬离体房室结标本的房室传导及血流的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1975;290(1):107-12. doi: 10.1007/BF00499993.
5
Effect of verapamil directly administered into A-V node artery on A-V junctional automaticity and A-V conduction in dogs.将维拉帕米直接注入犬房室结动脉对房室交界区自律性和房室传导的影响。
J Cardiovasc Pharmacol. 1985 Nov-Dec;7(6):1027-33. doi: 10.1097/00005344-198511000-00003.
6
Effects of TTX and verapamil on the upstroke components of the action potential from the atrioventricular node of the rabbit.河豚毒素和维拉帕米对兔房室结动作电位上升支成分的影响。
J Mol Cell Cardiol. 1978 Jan;10(1):95-107. doi: 10.1016/0022-2828(78)90009-3.
7
Cardioselective effects of gallopamil compared with verapamil in the dog heart.与维拉帕米相比，加洛帕米在犬心脏中的心脏选择性作用。
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Electrophysiologic effects of diltiazem in canine myocardium, with special reference to conduction delay during ischemia.地尔硫䓬对犬心肌的电生理效应，特别提及缺血期间的传导延迟。
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9
Modification by manganese ions and verapamil of the responses of the atrioventricular node to norepinephrine.锰离子和维拉帕米对房室结去甲肾上腺素反应的影响
Eur J Pharmacol. 1976 May;37(1):55-62. doi: 10.1016/0014-2999(76)90007-8.
10
The blockade of Vmax of the atrioventricular action potential produced by the slow channel inhibitors verapamil and nifedipine.
Naunyn Schmiedebergs Arch Pharmacol. 1981 Apr;316(2):178-85. doi: 10.1007/BF00505314.

引用本文的文献

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Cardiovascular effects of (R)- and (S)-verapamil and racemic verapamil in humans: a placebo-controlled study.（R）-维拉帕米、（S）-维拉帕米及消旋维拉帕米对人体心血管系统的影响：一项安慰剂对照研究。
Eur J Clin Pharmacol. 2006 Aug;62(8):613-9. doi: 10.1007/s00228-006-0154-7. Epub 2006 Jul 4.
2
Pharmacokinetics of (+)-, (-)- and (+/-)-verapamil after intravenous administration.静脉注射后（+）-、（-）-和（±）-维拉帕米的药代动力学
Br J Clin Pharmacol. 1984 Apr;17(4):453-8. doi: 10.1111/j.1365-2125.1984.tb02371.x.
3
Stereoselective first-pass metabolism of highly cleared drugs: studies of the bioavailability of L- and D-verapamil examined with a stable isotope technique.

本文引用的文献

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A simplified method of evaluating dose-effect experiments.一种评估剂量效应实验的简化方法。
J Pharmacol Exp Ther. 1949 Jun;96(2):99-113.
2
The cardiac conduction tissue and its blood supply in the dog.犬的心脏传导组织及其血液供应。
Am J Pathol. 1959 May-Jun;35(3):467-87.
3
Mechanism of cardiovascular action of tetrodotoxin in the cat. Block of conduction in peripheral sympathetic fibers.河豚毒素对猫心血管作用的机制。外周交感神经纤维传导阻滞。
高清除率药物的立体选择性首过代谢：用稳定同位素技术研究L-维拉帕米和D-维拉帕米的生物利用度
Br J Clin Pharmacol. 1984 Nov;18(5):733-40. doi: 10.1111/j.1365-2125.1984.tb02536.x.
4
The blockade of Vmax of the atrioventricular action potential produced by the slow channel inhibitors verapamil and nifedipine.
Naunyn Schmiedebergs Arch Pharmacol. 1981 Apr;316(2):178-85. doi: 10.1007/BF00505314.
5
Modulation of cardiac impulse generation and conduction by nifedipine and verapamil analyzed by a refined surface ECG technique in Langendorff perfused guinea pig hearts.通过改良的体表心电图技术在Langendorff灌注豚鼠心脏中分析硝苯地平和维拉帕米对心脏冲动产生和传导的调节作用。
Basic Res Cardiol. 1988 Mar-Apr;83(2):202-12. doi: 10.1007/BF01907274.
6
Cardiac versus coronary dilator effects of SD-3211, a new nondihydropyridine calcium antagonist, in isolated, blood-perfused dog hearts.新型非二氢吡啶类钙拮抗剂SD-3211在离体血液灌注犬心脏中的心脏与冠状动脉扩张作用
Cardiovasc Drugs Ther. 1990 Dec;4(6):1469-76. doi: 10.1007/BF02026494.
Circ Res. 1968 Oct;23(4):553-65. doi: 10.1161/01.res.23.4.553.
4
Effect of ischemia and low-sodium medium on atrioventricular conduction.缺血及低钠培养基对房室传导的影响。
Am J Physiol. 1970 May;218(5):1489-94. doi: 10.1152/ajplegacy.1970.218.5.1489.
5
The effect of tetrodotoxin on the membrane current in cardiac muscle (Purkinje fibers).河豚毒素对心肌（浦肯野纤维）膜电流的影响。
Pflugers Arch Gesamte Physiol Menschen Tiere. 1967;295(3):213-26. doi: 10.1007/BF01844101.
6
Selective suppression of neural excitation by tetrodotoxin injected into the canine atrioventricular node artery.通过向犬房室结动脉注射河豚毒素选择性抑制神经兴奋。
J Pharmacol Exp Ther. 1974 Jun;189(3):638-45.
7
Effects of agents which inhibit the slow channel on sinus node automaticity and atrioventricular conduction in the dog.抑制慢通道的药物对犬窦房结自律性和房室传导的影响。
Circ Res. 1974 Feb;34(2):184-92. doi: 10.1161/01.res.34.2.184.
8
Action of manganese ions and tetrodotoxin on atrioventricular nodal transmembrane potentials in isolated rabbit hearts.
Circ Res. 1973 Apr;32(4):447-54. doi: 10.1161/01.res.32.4.447.
9
Slow conduction in the atrioventricular node of the cat: a possible explanation.
Experientia. 1972 Dec 15;28(12):1442-3. doi: 10.1007/BF01957838.
10
The isolated and cross-circulated AV node preparation of the dog.犬的离体和交叉循环房室结标本
Tohoku J Exp Med. 1972 Jul;107(3):263-75. doi: 10.1620/tjem.107.263.