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The blockade of Vmax of the atrioventricular action potential produced by the slow channel inhibitors verapamil and nifedipine.

作者信息

Kohlhardt M, Haap K

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1981 Apr;316(2):178-85. doi: 10.1007/BF00505314.

DOI:10.1007/BF00505314
PMID:6264331
Abstract
摘要

相似文献

1
The blockade of Vmax of the atrioventricular action potential produced by the slow channel inhibitors verapamil and nifedipine.
Naunyn Schmiedebergs Arch Pharmacol. 1981 Apr;316(2):178-85. doi: 10.1007/BF00505314.
2
Comparison of the direct effects of nifedipine and verapamil on the electrical activity of the sinoatrial and atrioventricular nodes of the rabbit heart.硝苯地平与维拉帕米对兔心脏窦房结和房室结电活动直接影响的比较。
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3
Effects of TTX and verapamil on the upstroke components of the action potential from the atrioventricular node of the rabbit.河豚毒素和维拉帕米对兔房室结动作电位上升支成分的影响。
J Mol Cell Cardiol. 1978 Jan;10(1):95-107. doi: 10.1016/0022-2828(78)90009-3.
4
Effects of nifedipine, a potent calcium-antagonistic coronary vasodilator, on atrioventricular conduction and blood flow in the isolated atrioventricular node preparation of the dog.强效钙拮抗型冠状动脉扩张剂硝苯地平对犬离体房室结标本的房室传导及血流的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1975;290(1):107-12. doi: 10.1007/BF00499993.
5
Differential effects of organic slow inward current inhibitors, verapamil and nifedipine, on rate of atrioventricular rhythm and supraventricular tachycardia in the canine isolated, blood-perfused AV node preparation.有机性缓慢内向电流抑制剂维拉帕米和硝苯地平对犬离体、血液灌注房室结标本中房室节律和室上性心动过速速率的不同影响。
Naunyn Schmiedebergs Arch Pharmacol. 1981 Jan;315(3):241-8. doi: 10.1007/BF00499841.
6
Effect of nifedipine on atrioventricular conduction as compared with verapamil. Intracardiac electrophysiological study.硝苯地平与维拉帕米相比对房室传导的影响。心内电生理研究。
Br Heart J. 1979 Aug;42(2):124-7. doi: 10.1136/hrt.42.2.124.
7
Heart rate-dependent atrioventricular nodal conduction and the effects of calcium channel blocking drugs: comparison of verapamil and nifedipine.心率依赖性房室结传导及钙通道阻滞剂的作用：维拉帕米与硝苯地平的比较
J Cardiovasc Pharmacol. 1984 Mar-Apr;6(2):267-72. doi: 10.1097/00005344-198403000-00010.
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The effect of nifedipine on the sinus and atrioventricular node of the dog heart after beta-adrenergic receptor blockade.硝苯地平对β-肾上腺素能受体阻断后犬心脏窦房结和房室结的影响。
Acta Pharmacol Toxicol (Copenh). 1978 Apr;42(4):287-91. doi: 10.1111/j.1600-0773.1978.tb02203.x.
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Effects of verapamil on SA and AV nodal action potentials in the isolated rabbit heart.
Jpn Circ J. 1975 Aug;39(8):913-7. doi: 10.1253/jcj.39.913.
10
Effect of nifedipine and AQ-A 39 on the sinoatrial and atrioventricular nodes of the rabbit and their antiarrhythmic action on atrioventricular nodal reentrant tachycardia.硝苯地平与AQ - A 39对兔窦房结和房室结的作用及其对房室结折返性心动过速的抗心律失常作用。
Cardiovasc Res. 1983 Mar;17(3):132-44. doi: 10.1093/cvr/17.3.132.

引用本文的文献

1
Interaction between calcium and slow channel blocking drugs on atrial rate.钙与慢通道阻滞剂对心房率的相互作用。
Naunyn Schmiedebergs Arch Pharmacol. 1983 Feb;322(1):65-71. doi: 10.1007/BF00649354.
2
Saturation characteristics, Ca2+ ions and drug-induced block of cardiac Isi-mediated action potentials.饱和特性、钙离子与药物诱导的心脏内向整流钾电流（Isi）介导的动作电位阻滞
Naunyn Schmiedebergs Arch Pharmacol. 1983 Jul;323(3):251-60. doi: 10.1007/BF00497671.
3
Characterization of the effects of histamine on the transmembrane electrical activity of guinea-pig and rabbit SA- and AV-node cells.

本文引用的文献

1
Electrical activity of single fibers of the atrioventricular node.房室结单纤维的电活动。
Circ Res. 1959 Jan;7(1):11-8. doi: 10.1161/01.res.7.1.11.
2
Transmembrane potentials of single fibres of the atrio-ventricular node.
Nature. 1958 Jan 4;181(4601):66-7. doi: 10.1038/181066a0.
3
Slow current systems in the A-V node of the rabbit heart.
Nature. 1980 May 22;285(5762):228-9. doi: 10.1038/285228a0.
4
组胺对豚鼠和兔窦房结及房室结细胞跨膜电活动影响的特征描述。
Naunyn Schmiedebergs Arch Pharmacol. 1987 Aug;336(2):218-23. doi: 10.1007/BF00165808.
4
Biphasic dose-response relationship observed with Bay k 8644 on atrioventricular nodal conduction inhibited by verapamil.在用维拉帕米抑制的房室结传导中观察到Bay k 8644的双相剂量反应关系。
Naunyn Schmiedebergs Arch Pharmacol. 1988 Aug;338(2):196-201. doi: 10.1007/BF00174870.
5
Potentiation by acetylcholine of the effects of a calcium channel activator, Bay k 8644, on dog atria in situ.
Naunyn Schmiedebergs Arch Pharmacol. 1987 Mar;335(3):334-9. doi: 10.1007/BF00172807.
6
A method for estimation of drug affinity constants to the open conformational state of calcium channels.一种估算药物对钙通道开放构象状态亲和力常数的方法。
Biophys J. 1992 Sep;63(3):808-14. doi: 10.1016/S0006-3495(92)81636-3.
Two components of the cardiac action potential. I. Voltage-time course and the effect of acetylcholine on atrial and nodal cells of the rabbit heart.
心脏动作电位的两个组成部分。I. 电压-时间过程以及乙酰胆碱对兔心脏心房和节点细胞的影响。
J Gen Physiol. 1969 Nov;54(5):607-35. doi: 10.1085/jgp.54.5.607.
5
Action of manganese ions and tetrodotoxin on atrioventricular nodal transmembrane potentials in isolated rabbit hearts.
Circ Res. 1973 Apr;32(4):447-54. doi: 10.1161/01.res.32.4.447.
6
Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors.利用特异性抑制剂对哺乳动物心脏纤维中跨膜钠通道和钙通道进行区分。
Pflugers Arch. 1972;335(4):309-22. doi: 10.1007/BF00586221.
7
The effect of polarization on the action potentials of the rabbit AV nodal cells.极化对家兔房室结细胞动作电位的影响。
Jpn J Physiol. 1974 Dec;24(6):605-16. doi: 10.2170/jjphysiol.24.605.
8
Effect of verapamil on the sinoatrial and atrioventricular nodes of the rabbit and the mechanism by which it arrests reentrant atrioventricular nodal tachycardia.维拉帕米对兔窦房结和房室结的作用及其终止折返性房室结性心动过速的机制。
Circ Res. 1974 Sep;35(3):413-25. doi: 10.1161/01.res.35.3.413.
9
The interrelationship of calcium-mediated action potentials and tension development in cat ventricular myocardium.
J Mol Cell Cardiol. 1976 Apr;8(4):249-61. doi: 10.1016/0022-2828(76)90001-8.
10
The slow membrane channel as the predominant mediator of the excitation process of the sinoatrial pacemaker cell.
Basic Res Cardiol. 1976 Jan-Feb;71(1):17-26. doi: 10.1007/BF01907779.