Beck P, Venable R L, Hoff D L
J Clin Endocrinol Metab. 1975 Jul;41(1):44-53. doi: 10.1210/jcem-41-1-44.
Changes in iv glucose tolerance (IVGTT) and serum insulin responses to glucose infusion have been measured in intact female rhesus monkeys treated per os with norethindrone or medroxyprogesterone acetate (500 mug/day) both alone and in combination with mestranol or ethinyl estradiol (10 mug/day) orally for 3 weeks. When administered as the sole contraceptive steroid, neither norethindrone, medroxyprogesterone acetate, mestranol, or ethinyl estradiol produced consistent changes in fasting serum insulin or glucose concentration, mean intravenous serum glucose disappearance rates (K) or mean integrated serum insulin response to glucose (sigmal40). By contrast, concurrent administration of norethindrone with mestranol or ethinyl estradiol resulted in a significant increase in the fasting serum insulin concentration and the mean sigmal40. An increase in the mean K was also observed after norethindrone + mestranol. These results show that synthetic estrogens have the ability to potentiate the metabolic effects of norethindrone. However, the improvement in glucose tolerance produced in rhesus monkeys by concurrent mestranol + norethindrone treatment was marginal because of wide variation in glucose assimilation rates uncer control conditions. Thus, the IVGTT in the rhesus monkey appears to have limited use as a model for studying glucose homeostasis in man.
已对完整的雌性恒河猴进行了静脉注射葡萄糖耐量试验（IVGTT）以及测量了静脉输注葡萄糖后的血清胰岛素反应。这些恒河猴经口单独给予炔诺酮或醋酸甲羟孕酮（500微克/天），以及与炔雌醇或炔雌二醇（10微克/天）联合口服给药3周。当作为唯一的避孕甾体给药时，炔诺酮、醋酸甲羟孕酮、炔雌醇或炔雌二醇均未使空腹血清胰岛素或葡萄糖浓度、平均静脉血清葡萄糖消失率（K）或平均血清胰岛素对葡萄糖的综合反应（sigmal40）产生一致的变化。相比之下，炔诺酮与炔雌醇或炔雌二醇同时给药导致空腹血清胰岛素浓度和平均sigmal40显著增加。炔诺酮+炔雌醇给药后平均K也有所增加。这些结果表明，合成雌激素有增强炔诺酮代谢作用的能力。然而，由于对照条件下葡萄糖同化率变化很大，同时给予炔雌醇+炔诺酮治疗使恒河猴产生的葡萄糖耐量改善很有限。因此，恒河猴的IVGTT作为研究人类葡萄糖稳态的模型，其用途似乎有限。
