Beck P, Eaton R P, Arnett D M, Alsever R N
Metabolism. 1975 Sep;24(9):1055-65. doi: 10.1016/0026-0495(75)90099-2.
To evaluate the effect of contraceptive steroids on endogenous glucagon and insulin secretion, theta-arginine was infused intravenously in normal young women before and during selective steroid treatment. The effect of the combination of an estrogen derivative (mestranol), plus norethindrone (Norinyl, Syntex) was compared to the effect of ethinyl estradiol alone and to norethindrone alone. All three steroid schedules resulted in suppression of aminogenic insulin secretion. However, glucagon secretion was reduced only with ethinyl estradiol alone or the combination of mestranol plus norethindrone. In accordance with previous reports, treatment with an ethinyl estradiol derivative alone or in combination with norethindrone resulted in a tendency for elevated serum lipid concentration, while norethindrone alone resulted in a significant reduction in serum lipid concentration. These observations suggest an inverse relationship between aminogenic glucagon secretion and serum lipid concentration as influenced by contraceptive steroids. It is suggested that the metabolic effects of these steroids may be mediated in part by the associated alterations in pancreatic hormone secretory capacity.
为评估避孕类固醇对内源性胰高血糖素和胰岛素分泌的影响，在正常年轻女性接受选择性类固醇治疗之前及治疗期间，静脉输注θ-精氨酸。将雌激素衍生物（炔雌醇甲醚）加炔诺酮（诺雷得，先灵葆雅公司）的联合用药效果与单独使用乙炔雌二醇及单独使用炔诺酮的效果进行比较。所有三种类固醇用药方案均导致氨基生成性胰岛素分泌受到抑制。然而，仅乙炔雌二醇或炔雌醇甲醚加炔诺酮的联合用药可降低胰高血糖素分泌。与之前的报道一致，单独使用乙炔雌二醇衍生物或与炔诺酮联合使用会导致血清脂质浓度有升高趋势，而单独使用炔诺酮则会使血清脂质浓度显著降低。这些观察结果表明，受避孕类固醇影响，氨基生成性胰高血糖素分泌与血清脂质浓度之间存在负相关关系。提示这些类固醇的代谢效应可能部分由胰腺激素分泌能力的相关改变介导。
