Murialdo G, Masturzo P, Polleri A, Carolei A, Toffano G
Neuropsychobiology. 1979;5(6):317-21. doi: 10.1159/000117697.
Benserazide induces an increase of serum prolactin in man, possibly as the result of an impairment of the dopamine effect on the pituitary and/or on the outer median eminence caused by the inhibition on L-dopa decarboxylase. On the other hand, liposomes obtained from bovine brain cortex phospholipids reduced serum prolactin possibly through an effect of phosphatidylserine on dopamine biosynthesis at the level of tyrosine hydroxylase. Benserazide, given orally (125 mg) to 5 normal subjects, induced an increase of serum prolactin that did not change when 300 mg of phospholipid liposomes were given intravenously 60 min later. An increase of L-dopa synthesis does not seen to be capable to overcome the effects of the decarboxylase inhibition.
苄丝肼可使人体血清催乳素升高，这可能是由于左旋多巴脱羧酶受到抑制，削弱了多巴胺对垂体和/或外侧正中隆起的作用所致。另一方面，从牛脑皮质磷脂中提取的脂质体可能通过磷脂酰丝氨酸对酪氨酸羟化酶水平的多巴胺生物合成产生影响，从而降低血清催乳素。给5名正常受试者口服苄丝肼（125毫克）后，血清催乳素升高，60分钟后静脉注射300毫克磷脂脂质体时，血清催乳素并未改变。左旋多巴合成的增加似乎无法克服脱羧酶抑制的作用。
