大鼠输尿管的体内药理学。
The pharmacology of the rat ureter in vivo.
作者信息
Ancill R J, Jackson D M, Redfern P H
出版信息
Br J Pharmacol. 1972 Apr;44(4):628-33. doi: 10.1111/j.1476-5381.1972.tb07302.x.
Abstract
- A method of recording the peristaltic frequency and the rate of transport of fluid (perfusion rate) in the rat ureter in vivo is described.2. Acetylcholine and atropine did not alter ureteral activity. Histamine increased the rate of peristalsis by up to 15% and the rate of perfusion by up to 10%. Low doses of 5-hydroxytryptamine increased peristaltic frequency whereas high doses decreased peristaltic frequency; all doses reduced the rate of perfusion.3. Morphine reduced the rate of perfusion by 5-10% at all dose levels, but only the highest dose used reduced the frequency of ureteral peristalsis.4. (-)-Adrenaline, (-)-noradrenaline and (+/-)-isoprenaline reduced the frequency of peristalsis. The order of potency was isoprenaline>noradrenaline>adrenaline. The response was dose-related and blocked by propranolol, which itself did not affect ureteral activity.
摘要
描述了一种在活体大鼠输尿管中记录蠕动频率和液体输送速率（灌注速率）的方法。
乙酰胆碱和阿托品未改变输尿管活动。组胺使蠕动速率提高多达15%，灌注速率提高多达10%。低剂量的5-羟色胺增加蠕动频率，而高剂量则降低蠕动频率；所有剂量均降低灌注速率。
吗啡在所有剂量水平下均使灌注速率降低5 - 10%，但仅所用的最高剂量降低输尿管蠕动频率。
（-）-肾上腺素、（-）-去甲肾上腺素和（±）-异丙肾上腺素降低蠕动频率。效力顺序为异丙肾上腺素>去甲肾上腺素>肾上腺素。该反应与剂量相关，并被普萘洛尔阻断，而普萘洛尔本身不影响输尿管活动。
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本文引用的文献
1
2
SURGICAL PHYSIOLOGY OF THE RENAL PELVIS AND URETER.肾盂与输尿管的外科生理学
Monogr Surg Sci. 1964 Jun;1:173-213.
3
Ureteral contractility in the dog and the influence of drugs.狗的输尿管收缩性及药物的影响。
Arch Int Pharmacodyn Ther. 1960 Nov 1;128:291-8.
4
A study of the peristaltic conduction mechanism in the canine ureter.
J Urol. 1957 Sep;78(3):221-31. doi: 10.1016/S0022-5347(17)66427-9.
5
The effect of histamine on renal hemodynamics.
J Pharmacol Exp Ther. 1953 Oct;109(2):206-13.
6
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7
A method of investigating ureteral activity in the rat.一种研究大鼠输尿管活动的方法。
Br J Pharmacol. 1970 Feb;38(2):469P-470P.
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