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1
The effect of drugs on stress-induced changes of myocardial glycogen and blood glucose concentration in rats.药物对大鼠应激诱导的心肌糖原和血糖浓度变化的影响。
Br J Pharmacol. 1972 Apr;44(4):814-6. doi: 10.1111/j.1476-5381.1972.tb07321.x.
2
Effect of alpha-methyltyrosine on stress-induced changes in seizure susceptibility.
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An investigation of alpha-methyl amino-acids and their derivatives on isolated tissue preparations.α-甲基氨基酸及其衍生物对离体组织标本的研究。
Br J Pharmacol. 1970 Dec;40(4):689-701. doi: 10.1111/j.1476-5381.1970.tb10647.x.
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Stress-related effects of various inhibitors of catecholamine synthesis in the mouse.小鼠中儿茶酚胺合成的各种抑制剂与应激相关的作用。
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Saligenin analogs of l-DOPA and dl-alpha-methyl-DOPA.左旋多巴和消旋α-甲基多巴的水杨苷类似物。
J Med Chem. 1974 Feb;17(2):248-9. doi: 10.1021/jm00248a026.
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[Effects of alpha-methyl-p-tyrosine and cold stress on tissue norepinephrine, plasma NFFA, glucose and colonic temperature in warm- and cold-acclimated rats].
Nihon Yakurigaku Zasshi. 1972 May;68(3):363-76. doi: 10.1254/fpj.68.363.
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Effect of short-term immobilization at different times of day on circadian blood glucose and tissue glycogen oscillations in the rat.一天中不同时间短期固定对大鼠昼夜血糖和组织糖原振荡的影响。
Physiol Bohemoslov. 1983;32(2):171-8.
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Studies on the interrelationship between the syntheses of noradrenaline and metaraminol.去甲肾上腺素与间羟胺合成之间的相互关系研究。
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Effect of combination of stresses on myocardial metabolism.多种应激因素联合作用对心肌代谢的影响。
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10
Physiological effects of "social stress" in wild rats--II. Liver glycogen and blood glucose.野生大鼠“社会应激”的生理效应——II. 肝糖原与血糖
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本文引用的文献

1
Notes on sugar determination.糖分测定笔记。
J Biol Chem. 1952 Mar;195(1):19-23.
2
Improved restraint-technique for producing stress and cardiac necrosis in rats.用于在大鼠中产生应激和心脏坏死的改良束缚技术。
J Appl Physiol. 1959 Sep;14:868-9. doi: 10.1152/jappl.1959.14.5.868.
3
The effects of alpha-methyl-DOPA and alpha-methyl-metatyrosine on the metabolism of norepinephrine and serotonin in vivo.α-甲基多巴和α-甲基间酪氨酸对体内去甲肾上腺素和5-羟色胺代谢的影响。
J Pharmacol Exp Ther. 1961 Nov;134:129-38.
4
Sympathogenic origin and antiadrenergic prevention of stress-induced myocardial lesions.应激性心肌损伤的交感神经源性及抗肾上腺素能预防
Am J Cardiol. 1961 Aug;8:203-11. doi: 10.1016/0002-9149(61)90207-7.
5
A colorimetric micro-method for the determination of glycogen in tissues.一种用于测定组织中糖原的比色微量法。
Biochem J. 1954 Apr;56(4):646-8. doi: 10.1042/bj0560646.
6
Effect of chlorpromazine, mecamylamine and guanethidine on the cold stress induced changes in myocardial glycogen and acetylcholine content in rabbits.氯丙嗪、美加明和胍乙啶对家兔冷应激诱导的心肌糖原和乙酰胆碱含量变化的影响。
Indian J Med Res. 1967 Jan;55(1):60-72.
7
Inhibition of dopamine-beta-hydroxylase by disulfiram in vivo.双硫仑在体内对多巴胺-β-羟化酶的抑制作用。
J Pharmacol Exp Ther. 1966 Apr;152(1):56-61.
8
Presence of alpha-methyl-DOPA metabolites in heart and brain of guinea pigs treated with alpha-methyl-tyrosine.用α-甲基酪氨酸处理的豚鼠心脏和大脑中α-甲基多巴代谢物的存在情况。
Life Sci. 1965 Dec;4(23):2249-56. doi: 10.1016/0024-3205(65)90245-6.

药物对大鼠应激诱导的心肌糖原和血糖浓度变化的影响。

The effect of drugs on stress-induced changes of myocardial glycogen and blood glucose concentration in rats.

作者信息

Prabhu S, Sharma V N, Singh V

出版信息

Br J Pharmacol. 1972 Apr;44(4):814-6. doi: 10.1111/j.1476-5381.1972.tb07321.x.

DOI:10.1111/j.1476-5381.1972.tb07321.x
PMID:5041457
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1665983/
Abstract

Rats that were subjected to restraint stress for 18 h were found to have reduced myocardial glycogen and blood sugar levels and showed histological changes in heart and adrenals. The effects of alpha-methyl-p-tyrosine, alpha-methyl-dopa, disulfiram and actinomycin D on these stress-induced changes were examined. Of these drugs, only alpha-methyl-p-tyrosine was able to prevent the fall in myocardial glycogen and blood sugar and none of the drugs prevented the histological changes induced by stress.

摘要

经18小时束缚应激的大鼠被发现心肌糖原和血糖水平降低，并在心脏和肾上腺出现组织学变化。研究了α-甲基对酪氨酸、α-甲基多巴、双硫仑和放线菌素D对这些应激诱导变化的影响。在这些药物中，只有α-甲基对酪氨酸能够防止心肌糖原和血糖下降，且没有一种药物能防止应激诱导的组织学变化。