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α-甲基氨基酸及其衍生物对离体组织标本的研究。

An investigation of alpha-methyl amino-acids and their derivatives on isolated tissue preparations.

作者信息

Gulati O D, Parikh H M, Ringe S Y, Sherlekar M L

出版信息

Br J Pharmacol. 1970 Dec;40(4):689-701. doi: 10.1111/j.1476-5381.1970.tb10647.x.

DOI:10.1111/j.1476-5381.1970.tb10647.x
PMID:5495174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1702915/
Abstract
  1. The ability of alpha-methyl amino-acids and their corresponding amines to restore the sympathomimetic actions of tyramine, and the uptake of the amino-acids and the amines, were studied in isolated tissue preparations obtained from reserpine pretreated animals.2. Tyramine relaxed isolated rat ileum preparations from non-reserpinized rats but not from reserpine treated animals. alpha-Methyldopa, alpha-methylnoradrenaline and lower concentrations of metaraminol restored the responses of reserpinized preparations. alpha-Methyldopamine, alpha-methyl-m-tyrosine, alpha-methyl-p-tyrosine and higher concentrations of metaraminol did not do so. The restoring effect of alpha-methyldopa was blocked by disulphiram. alpha-Methyl-p-tyrosine or alpha-methyl-m-tyrosine blocked the restoring action of alpha-methyldopa but not of alpha-methylnoradrenaline. Cocaine blocked the restoration of responses to tyramine by alpha-methylnoradrenaline but not by alpha-methyldopa. alpha-Methyldopa and alpha-methylnoradrenaline failed to restore responses to tyramine in the presence of sodium-free Tyrode solution.3. Tyramine increased the perfusion pressure in isolated rabbit ear preparations obtained from non-reserpinized animals but was very much less active in preparations obtained from reserpine treated animals. alpha-Methyldopa, alpha-methyl-m-tyrosine, alpha-methylnoradrenaline, alpha-methyl-p-tyrosine and metaraminol restored the effects of tyramine. alpha-Methyldopamine did not do so. The restoring effect of alpha-methyldopa and alpha-methyl-m-tyrosine was blocked by disulfiram. alpha-Methyl-p-tyrosine blocked the restoring effect of alpha-methyl-m-tyrosine.4. Tyramine produced positive inotropic effects in isolated rabbit heart preparations. This was either reduced or absent in preparations obtained from reserpine pretreated animals. alpha-Methyldopa, alpha-methylnoradrenaline, alpha-methyl-m-tyrosine and metaraminol restored the responses to tyramine. alpha-Methyldopamine and alpha-methyl-p-tyrosine did not do so.
摘要

  1. 在从经利血平预处理的动物获得的离体组织制备物中，研究了α-甲基氨基酸及其相应胺类恢复酪胺拟交感神经作用的能力，以及氨基酸和胺类的摄取情况。

  2. 酪胺可使未用利血平处理的大鼠的离体回肠制备物松弛，但对经利血平处理的动物的制备物则无此作用。α-甲基多巴、α-甲基去甲肾上腺素和较低浓度的间羟胺可恢复经利血平处理的制备物的反应。α-甲基多巴胺、α-甲基间酪氨酸、α-甲基对酪氨酸和较高浓度的间羟胺则不能。α-甲基多巴的恢复作用被双硫仑阻断。α-甲基对酪氨酸或α-甲基间酪氨酸可阻断α-甲基多巴的恢复作用，但不阻断α-甲基去甲肾上腺素的恢复作用。可卡因可阻断α-甲基去甲肾上腺素对酪胺反应的恢复作用，但不阻断α-甲基多巴的恢复作用。在无钠的台氏液存在下，α-甲基多巴和α-甲基去甲肾上腺素未能恢复对酪胺的反应。

  3. 酪胺可使从未用利血平处理的动物获得的离体兔耳制备物的灌注压升高，但对经利血平处理的动物的制备物的作用则弱得多。α-甲基多巴、α-甲基间酪氨酸、α-甲基去甲肾上腺素、α-甲基对酪氨酸和间羟胺可恢复酪胺的作用。α-甲基多巴胺则不能。α-甲基多巴和α-甲基间酪氨酸的恢复作用被双硫仑阻断。α-甲基对酪氨酸可阻断α-甲基间酪氨酸的恢复作用。

  4. 酪胺可使离体兔心制备物产生正性肌力作用。在经利血平预处理的动物的制备物中，这种作用要么减弱要么消失。α-甲基多巴、α-甲基去甲肾上腺素、α-甲基间酪氨酸和间羟胺可恢复对酪胺的反应。α-甲基多巴胺和α-甲基对酪氨酸则不能。

相似文献

1
An investigation of alpha-methyl amino-acids and their derivatives on isolated tissue preparations.α-甲基氨基酸及其衍生物对离体组织标本的研究。
Br J Pharmacol. 1970 Dec;40(4):689-701. doi: 10.1111/j.1476-5381.1970.tb10647.x.
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Restoration of the chronotropic effect of tyramine on rat atria after reserpine.利血平处理后酪氨酸对大鼠心房变时作用的恢复。
Br J Pharmacol. 1968 Sep;34(1):88-98. doi: 10.1111/j.1476-5381.1968.tb07953.x.
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SOME OBSERVATIONS ON THE PHARMACOLOGY OF ALPHA-METHYLDOPA.关于α-甲基多巴药理学的一些观察
Br J Pharmacol Chemother. 1964 Feb;22(1):72-86. doi: 10.1111/j.1476-5381.1964.tb01545.x.
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Effect of alpha-methyldopa and alpha-methyl-m-tyrosine on the mobilization of free fatty acids.α-甲基多巴和α-甲基间酪氨酸对游离脂肪酸动员的影响。
Experientia. 1964 Sep 15;20(9):495-6. doi: 10.1007/BF02154069.
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Effect of methyldopa and related agents on pressor responses to tyramine in reserpine-pretreated rats and dogs.甲基多巴及相关药物对利血平预处理的大鼠和犬对酪胺升压反应的影响。
J Pharmacol Exp Ther. 1966 Feb;151(2):242-52.
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False neurochemical transmitters and response to tyramine in reserpine pretreated preparations.利血平预处理制剂中的假性神经化学递质及对酪胺的反应
Life Sci. 1965 Jul;4(13):1281-7. doi: 10.1016/0024-3205(65)90077-9.
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Relation between molecular configuration and certain biological actions of alpha-methyldopamine and alpha-methyl-meta-tyramine and their beta-hydroxylated products alpha-methylnorepinephrine and metaraminol.α-甲基多巴胺和α-甲基间酪氨酸及其β-羟基化产物α-甲基去甲肾上腺素和间羟胺的分子构型与某些生物学作用之间的关系。
Arch Int Pharmacodyn Ther. 1968 Jul;174(1):118-34.
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[On the significance of the noradrenaline content of fatty tissue for the mobilization of unesterified fatty acids].[论脂肪组织中去甲肾上腺素含量对非酯化脂肪酸动员的意义]
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 Sep 27;251(5):465-87.
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Methyldopa abolishes neurally evoked contractions of the vas deferens in vitro.甲基多巴在体外可消除输精管的神经诱发收缩。
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Pharmacology of alpha-methyl DOPA and alpha-methylnoradrenaline.α-甲基多巴和α-甲基去甲肾上腺素的药理学
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本文引用的文献

1
Aromatic L-amino acid decarboxylase.芳香族L-氨基酸脱羧酶
J Biol Chem. 1962 Jan;237:89-93.
2
MECHANISM OF AMINE TRANSPORT IN THE CELL MEMBRANES OF THE ADRENERGIC NERVES.肾上腺素能神经细胞膜中胺类转运的机制
Acta Pharmacol Toxicol (Copenh). 1965;22:293-300. doi: 10.1111/j.1600-0773.1965.tb01824.x.
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BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE.酪氨酸羟化酶抑制剂α-甲基酪氨酸对内源性去甲肾上腺素合成的阻断作用
J Pharmacol Exp Ther. 1965 Jan;147:86-95.
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THE NOREPINEPHRINE STORES OF ISOLATED ATRIA OF GUINEA PIGS PRETREATED WITH RESERPINE.用利血平预处理的豚鼠离体心房的去甲肾上腺素储备
J Pharmacol Exp Ther. 1964 Aug;145:151-61.
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INHIBITION OF DOPAMINE-BETA-HYDROXYLASE BY DISULFIRAM.双硫仑对多巴胺-β-羟化酶的抑制作用
Life Sci (1962). 1964 Jul;3:763-7. doi: 10.1016/0024-3205(64)90031-1.
6
EFFECT OF INFUSIONS OF SYMPATHOMIMETIC AMINES ON THE RESPONSE OF SPINAL CATS TO TYRAMINE AND TO SYMPATHETIC STIMULATION.拟交感胺输注对脊髓猫对酪胺及交感神经刺激反应的影响
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1964 Apr 21;248:39-53. doi: 10.1007/BF00247058.
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THE METABOLISM OF METHYLDOPA IN HYPERTENSIVE HUMAN SUBJECTS.甲基多巴在高血压患者中的代谢
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8
SOME OBSERVATIONS ON THE PHARMACOLOGY OF ALPHA-METHYLDOPA.关于α-甲基多巴药理学的一些观察
Br J Pharmacol Chemother. 1964 Feb;22(1):72-86. doi: 10.1111/j.1476-5381.1964.tb01545.x.
9
RELEASE BY SYMPATHETIC STIMULATION OF ALPHA-METHYLNORADRENALINE STORED IN THE HEART AFTER ADMINISTRATION OF ALPHA-METHYLDOPA.服用α-甲基多巴后，交感神经刺激使储存于心脏的α-甲基去甲肾上腺素释放。
Experientia. 1963 Dec 15;19:658-9. doi: 10.1007/BF02151307.
10
ENHANCEMENT BY METHYLDOPA OF TYRAMINE SENSITIVITY IN MAN.甲基多巴对人体酪胺敏感性的增强作用。
Nature. 1963 Dec 14;200:1107-8. doi: 10.1038/2001107a0.