Lemberger L, Crabtree R E, Rowe H M
Science. 1972 Jul 7;177(4043):62-4. doi: 10.1126/science.177.4043.62.
11-Hydroxy-Delta(9)-tetrahydrocannabinol, administered intravenously to man, produces psychologic and pharmacologic effects that persist for several hours. The drug and its metabolites are excreted in urine and feces for more than 1 week. The pharmacology, disposition, and metabolism of 11-hydroxy-Delta(9)-tetra-hydrocannabinol mimic that of Delta(9)-tetrahydrocannabinol, thus providing evidence that Delta(9)-tetrahydrocannabinol (the major active component of marihuana) is converted to the 11-hydroxy compound in man, the latter compound being responsible for the effects.
11-羟基-Δ(9)-四氢大麻酚静脉注射给人体后，会产生持续数小时的心理和药理作用。该药物及其代谢产物在尿液和粪便中排泄超过1周。11-羟基-Δ(9)-四氢大麻酚的药理、处置和代谢与Δ(9)-四氢大麻酚相似，从而证明Δ(9)-四氢大麻酚（大麻的主要活性成分）在人体内会转化为11-羟基化合物，后者产生这些作用。
