Pain accompanying leg venography: a comparison of sodium and methylglucamine diatrizoates.

Leg venography with either 50% sodium diatrizoate or 60% meglumine diatrizoate was performed on 31 patients suspected of having deep venous thrombophlebitis. Four of 14 patients receiving meglumine diatrizoate experienced pain during venography, as compared to 14 of 17 patients receiving sodium diatrizoate (p less than 0.004). A second study showed no statistically significant difference in the incidence of pain between two groups of patients receiving either Renografin-45 (6% sodium diatrizoate, 39% meglumine diatrizoate) or Renografin-M-45 (45% meglumine diatrizoate).