邻氯对硝基苯甲醚（OCNA）和邻氯对氨基苯甲醚（OCPA）的急性毒性（作者译）
[Acute toxicity of orthochloroparanitroanisole (OCNA) and orthochloroparaanisidine (OCPA) (author's transl)].
作者信息
Gradiski D, Duprat P, Magadur J L, Poitou P
出版信息
Toxicol Eur Res. 1979 Mar;2(2):77-86.
The acute effects of two industrial substances were studied in mice, rats, rabbits and guinea pigs: - lethal concentration 50 (L.D. 50) in mice and rats after intraperitoneal and oral administration; - investigation of cell growth inhibition (Hela cells), I.D.50 = inhibitory dose 50%; - neuropharmacological effects Histopathological investigations and biochemical analysis pointed out hepatic and renal damages; besides hematological disturbances were found. Both products had mild irritant effects on rabbits skin and eyes. They produced skin sensitization in guinea pigs.
在小鼠、大鼠、兔子和豚鼠身上研究了两种工业物质的急性效应：- 腹腔注射和口服给药后小鼠和大鼠的半数致死浓度（L.D. 50）；- 细胞生长抑制研究（海拉细胞），I.D.50 = 半数抑制剂量；- 神经药理学效应 组织病理学研究和生化分析指出了肝脏和肾脏损伤；此外还发现了血液学紊乱。两种产品对兔子的皮肤和眼睛都有轻微刺激作用。它们在豚鼠身上引起了皮肤过敏。
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