[氯甲酸 -1-萘酯与邻异丙氧基硝基苯的急性毒性]

[Acute toxicity of l-naphthyl chlorocarbonate and o-isopropoxynitrobenzene].

作者信息

Barański B, Krysiak B, Czajkowska T, Knobloch K, Stetkiewicz I

出版信息

Med Pr. 1978;29(4):293-9.

Abstract

The investigated compounds given orally to male rats induced pathological changes mainly in the liver. 1-naphthyl chlorocarbonate caused also necrosis of the stomach mucosa. DL50 of o-isopropoxynitrobenzene and 1-naphthyl chlorocarbonate established for male rats after per os administration amounted to 2,75 g/kg and 2,55 g/kg, respectively. Both substances have local irritant effect on the skin and the eye of rabbit--a mild reaction in case of o-isopropoxynitrobenzene and strong one in case of 1-naphthyl chlorocarbonate administration. 1-naphthyl chlorocarbonate has sensitizing properties, while the other compound has not.

摘要

给雄性大鼠口服受试化合物后，主要在肝脏引发了病理变化。氯甲酸-1-萘酯还导致胃黏膜坏死。经口给药后，雄性大鼠的邻异丙氧基硝基苯和氯甲酸-1-萘酯的半数致死剂量分别为2.75克/千克和2.55克/千克。这两种物质对兔的皮肤和眼睛均有局部刺激作用——邻异丙氧基硝基苯引起轻度反应，而氯甲酸-1-萘酯引起强烈反应。氯甲酸-1-萘酯具有致敏性，而另一种化合物则没有。

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