Barry K J, Scott R M
Stroke. 1979 Sep-Oct;10(5):535-7. doi: 10.1161/01.str.10.5.535.
The cat basilar artery was exposed using the transclival approach. After administration of 5% ethanol via intravenous infusion, vasospasm was produced by applying the animal's fresh arterial blood to the exposed artery. The resultant vasospasm was of markedly reduced intensity and duration as compared to vasospasm in control animals. In ethanol-treated animals with spasm induced from non-autogenous fresh arterial bloof free of ethanol, a reduction in the duration of vasospasm was noted although the initial intensity of spasm was similar to control animals. There was no anti-spasm effect if the ethanol infusion followed the production of vasospasm.
采用经斜坡入路暴露猫的基底动脉。经静脉输注5%乙醇后，将动物的新鲜动脉血涂抹于暴露的动脉上以诱发血管痉挛。与对照动物的血管痉挛相比，由此产生的血管痉挛强度和持续时间明显降低。在经乙醇处理的动物中，用不含乙醇的非自体新鲜动脉血诱发痉挛时，尽管痉挛的初始强度与对照动物相似，但血管痉挛的持续时间有所缩短。如果在血管痉挛产生后输注乙醇，则没有抗痉挛作用。
