Flamm E S, Kim J, Lin J, Ransohoff J
Arch Neurol. 1975 Aug;32(8):569-71. doi: 10.1001/archneur.1975.00490500089013.
Experimental cerebral vasospasm was studied in cat and monkey models. In the cat, the basilar artery was exposed by a transclival approach and spasm induced by the application of blood to the vessel. In the monkey, spasm was produced by injecting blood into the subarachnoid space. Vessel size was determined in the cat by direct observation and, in the monkey, by cerebral angiography. Several agents known to alter the synthsis and degradation of cyclic adenosine monophosphate (AMP) were used to modity the vasospasm produced. Isoproterenol (Norisodrine) and aminophyline were effective in reversing cerebral vasospasm when applied topically and when administered parenterally. It is suggested that manipulation of the cyclic AMP pathways may be an effective method of controlling cerebral vasospasm.
在猫和猴子模型中研究了实验性脑血管痉挛。在猫中，通过经斜坡入路暴露基底动脉，并通过向血管施加血液诱导痉挛。在猴子中，通过将血液注入蛛网膜下腔产生痉挛。在猫中通过直接观察确定血管大小，在猴子中通过脑血管造影确定。使用几种已知可改变环磷酸腺苷（AMP）合成和降解的药物来调节产生的血管痉挛。异丙肾上腺素（去甲异肾上腺素）和氨茶碱局部应用和胃肠外给药时可有效逆转脑血管痉挛。提示操纵环磷酸腺苷途径可能是控制脑血管痉挛的有效方法。
