产生D型肿瘤病毒的细胞的分子杂交研究。
Molecular hybridization study of cells producing oncornaviruses type D.
作者信息
Zhdanov V M, Mazurenko N N, Demidova S A
出版信息
Neoplasma. 1975;22(1):3-11.
PMID:50568
Abstract
Five human cell lines producing oncornaviruses type D were studied by the method of molecular hybridization of viral and cellular nucleic acids. Repeated sequences of viral genome equivalents were found in nuclear DNA and numerous copies of viral genome were found in the cytoplasm. The viruses produced by the cell lines were found to be identical or closely related as regards nucleotide sequences of their genomes.
摘要
采用病毒与细胞核酸分子杂交的方法，对5株产生D型肿瘤病毒的人细胞系进行了研究。在核DNA中发现了病毒基因组等效物的重复序列，在细胞质中发现了大量病毒基因组拷贝。结果发现，这些细胞系产生的病毒在基因组核苷酸序列方面是相同的或密切相关的。
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