Savu L, Nunez E, Jayle M F
Steroids. 1975 Jun;25(6):717-28. doi: 10.1016/0039-128x(75)90036-7.
High diethylstilboestrol (DES) binding has been demonstrated in fetal and adult sera from man, rat and mouse by equilibrium dialysis and electrophoretic techniques. In the adults of the three species and in the human fetus only albumin shows an elevated binding capacity for DES. By contrast, in the case of rat and mouse embryos there are two proteins, namely albumin and alpha-fetoprotein, which afford major and quantatively similar contributions to the binding. Human alpha-fetoprotein does not bind DES. These phenomena are analysed in relation to the estrogen binding characteristics of the alpha-fetoproteins of the three species.
通过平衡透析和电泳技术已证明，在人类、大鼠和小鼠的胎儿及成年血清中，己烯雌酚（DES）结合力较高。在这三个物种的成年个体以及人类胎儿中，只有白蛋白对DES的结合能力有所提高。相比之下，在大鼠和小鼠胚胎中，有两种蛋白质，即白蛋白和甲胎蛋白，它们对结合的贡献主要且在数量上相似。人类甲胎蛋白不结合DES。结合这三个物种甲胎蛋白的雌激素结合特性对这些现象进行了分析。
