Orbuch S J, Findor J A
Acta Gastroenterol Latinoam. 1979;9(2):73-80.
A case of a 49 year old patient suffering from ulcerative colitis and chronic hepatitis with cirrothic transformation is presented who under prolonged immunosuppressive treatment with azathioprine 50 mg daily and 10 mg daily of prednisone developed Hodgkins disease whose diagnosis was at the autopsy. The association between hepatic cirrhosis and lymphoproliferative disorders such as lymphosarcoma and lymphatic leukemia were already described (19,20). Recently, an article was published on a similar case to ours (23) in which the patient, suffering from chronic hepatopathy submitted to azathioprine and corticoids, developed Hodgkin's disease. The link between ulcerative colitis, the chronic hepatopathy and the development of Hodgkin's disease that could have arisen as a consequence of the prolonged immunosuppressive treatment are discussed. The apparition of malignancies in patients submitted to immunosuppression owing to renal transplantation are compared with the apparition of malignancies in patients submitted to immunosuppression because of a number of other diseases.
本文报告一例49岁患有溃疡性结肠炎和慢性肝炎并伴有肝硬化转变的患者，该患者在接受每日50毫克硫唑嘌呤和每日10毫克泼尼松的长期免疫抑制治疗后患上了霍奇金病，其诊断是在尸检时做出的。肝硬化与淋巴增殖性疾病如淋巴肉瘤和淋巴性白血病之间的关联已被描述过（19,20）。最近，发表了一篇与我们的病例类似的文章（23），其中患者患有慢性肝病并接受硫唑嘌呤和皮质类固醇治疗，发展为霍奇金病。讨论了溃疡性结肠炎、慢性肝病与可能因长期免疫抑制治疗而引发的霍奇金病之间的联系。将肾移植患者因免疫抑制而出现恶性肿瘤的情况与因其他多种疾病接受免疫抑制的患者出现恶性肿瘤的情况进行了比较。
