一种新的乙型肝炎表面抗原病毒特异性决定簇。

A new virus specified determinant of hepatitis B surface antigen.

作者信息

Magnius L, Kaplan L, Vyas G N, Perkins H A

出版信息

Acta Pathol Microbiol Scand B. 1975 Jun;83(3):295-7. doi: 10.1111/j.1699-0463.1975.tb00104.x.

DOI:10.1111/j.1699-0463.1975.tb00104.x

Abstract

One hundred and three samples from hepatitis B surface antigen (HB(s)Ag) positive Californian blood donors were subtyped in immunodiffusion with respect to d/y, w/r and a21, a23, a3. Spur formation with a human antiserum indicated a previously unrecognized determinant q, which was detected in 96 sera (4 a21yw, 15 a23yw, 69 a21dw and 8 adr). Out of 8 sera which by spur formation were demonstrated to lack q, 7 were further subtyped (2 a21dw and 5 a3dw). Hence all 5 a3 dw specimens were demonstrated to lack q, thus indicating that q is specified by the virus. The possible relation of q to x with further implications for the specification of x is discussed.

摘要

对来自加利福尼亚州的103份乙肝表面抗原（HB(s)Ag）阳性献血者样本，采用免疫扩散法针对d/y、w/r以及a21、a23、a3进行亚型分型。用一种人抗血清出现沉淀线表明存在一种先前未识别的决定簇q，在96份血清中检测到该决定簇（4份a21yw、15份a23yw、69份a21dw和8份adr）。在8份经沉淀线显示缺乏q的血清中，7份进一步进行了亚型分型（2份a21dw和5份a3dw）。因此，所有5份a3 dw样本均显示缺乏q，这表明q由病毒所决定。文中讨论了q与x的可能关系以及对x决定簇的进一步影响。