兔体内氢化蒽酮的代谢
Metabolism of hydroanthracenones in rabbits.
作者信息
Robertson J S, Dunstan P J
出版信息
Biochem J. 1972 Mar;127(1):119-23. doi: 10.1042/bj1270119.
Abstract
- The metabolism of 1-oxo-octahydro- and 2- and 9-oxoperhydro-anthracenes was investigated in rabbits. All compounds increased the urinary glucuronide content. 2. The 1-oxo and 2-oxo compounds were reduced to the corresponding alcohols whereas the 9-oxo compound was hydroxylated. 3. The reduction in vitro of these compounds and related ketones was investigated with three different enzyme systems (liver alcohol dehydrogenase, hydroxy steroid dehydrogenase, aromatic aldehyde-ketone reductase) in an attempt to explain the results in vivo. 4. Successful reduction of many ketones with aromatic aldehyde-ketone reductase suggests that the kidney may be of importance in the reduction in vivo of certain cyclic carbonyl compounds.
摘要
- 在兔子身上研究了1-氧代八氢蒽以及2-和9-氧代全氢蒽的代谢情况。所有化合物均使尿中葡糖醛酸苷含量增加。2. 1-氧代和2-氧代化合物被还原为相应的醇，而9-氧代化合物发生了羟基化。3. 用三种不同的酶系统（肝脏乙醇脱氢酶、羟基类固醇脱氢酶、芳香醛 - 酮还原酶）研究了这些化合物及相关酮类在体外的还原情况，以试图解释体内的实验结果。4. 芳香醛 - 酮还原酶成功还原了许多酮类，这表明肾脏在体内某些环状羰基化合物的还原过程中可能起重要作用。
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