兔体内全氢蒽的代谢
Metabolism of perhydroanthracenes in the rabbit.
作者信息
Robertson J S, Dunstan P J
出版信息
Biochem J. 1971 Sep;124(3):543-7. doi: 10.1042/bj1240543.
Abstract
- The metabolism in rabbits of several perhydroanthracenes was investigated. All compounds were to different degrees excreted in the urine as glucuronides. 2. The aglycones of the glucuronides were found to be racemic secondary alcohols, having the hydroxyl group at a beta-methylene carbon. Where determinable, the hydroxyl group was shown to have an equatorial configuration. 3. These results suggested that hydroxylation was enzyme mediated, and, when compared with the results from studies on other alicyclic hydrocarbons, that the same enzyme system participated generally in the hydroxylation of such hydrocarbons. 4. A model for the enzyme active site is proposed to accord with the pattern of hydroxylation observed.
摘要
- 对几种全氢蒽在兔体内的代谢进行了研究。所有化合物都不同程度地以葡糖醛酸苷的形式经尿液排出。2. 发现葡糖醛酸苷的苷元是外消旋仲醇，羟基位于β-亚甲基碳上。在可测定的情况下，羟基呈平伏构型。3. 这些结果表明羟基化是由酶介导的，并且与其他脂环烃的研究结果相比，同一酶系统通常参与此类烃的羟基化。4. 提出了一个酶活性位点模型，以符合所观察到的羟基化模式。
相似文献
1
Metabolism of perhydroanthracenes in the rabbit.兔体内全氢蒽的代谢
Biochem J. 1971 Sep;124(3):543-7. doi: 10.1042/bj1240543.
2
Metabolism of methyldecalins.甲基十氢化萘的代谢
Biochem J. 1970 Sep;119(2):299-302. doi: 10.1042/bj1190299.
3
The metabolism of the isomeric decalones.异构十氢化萘的代谢
Biochem J. 1966 Aug;100(2):393-402. doi: 10.1042/bj1000393.
4
Metabolism of hydroanthracenones in rabbits.兔体内氢化蒽酮的代谢
Biochem J. 1972 Mar;127(1):119-23. doi: 10.1042/bj1270119.
5
Quaternary N-glucuronides of 10-hydroxylated amitriptyline metabolites in human urine.人尿中10-羟基阿米替林代谢物的季铵N-葡萄糖醛酸苷。
Xenobiotica. 1990 Jul;20(7):727-38. doi: 10.3109/00498259009046888.
6
The metabolism of 5,7-dinitroindazole in the mouse and the rat.
Xenobiotica. 1973 Aug;3(8):511-24. doi: 10.3109/00498257309151539.
7
Stereoselective aliphatic hydroxylation of 6-n-propylchromone-2-carboxylic acid by female Dutch rabbits.雌性荷兰兔对6-正丙基色酮-2-羧酸的立体选择性脂肪族羟基化作用
Chirality. 1992;4(1):1-7. doi: 10.1002/chir.530040103.
8
Metabolism of beta-ionone. Isolation, characterization and identification of the metabolitesin the urine of rabbits.β-紫罗兰酮的代谢。家兔尿液中代谢产物的分离、表征与鉴定。
Biochem J. 1970 Sep;119(2):281-7. doi: 10.1042/bj1190281.
9
On the rate-limiting step in W-hydroxylation of lauric acid.关于月桂酸ω-羟基化反应中的限速步骤。
Biochem Biophys Res Commun. 1972 Apr 28;47(2):333-40. doi: 10.1016/0006-291x(72)90717-6.
10
Metabolism of pronethalol in the rat, the guinea pig and the mouse.丙萘洛尔在大鼠、豚鼠和小鼠体内的代谢。
Res Commun Chem Pathol Pharmacol. 1974 Dec;9(4):601-19.
引用本文的文献
1
Metabolism of hydroanthracenones in rabbits.兔体内氢化蒽酮的代谢
Biochem J. 1972 Mar;127(1):119-23. doi: 10.1042/bj1270119.
本文引用的文献
1
A study of the determination of glucuronic acid by the naphthoresorcinol reaction, with the photoelectric absorptiometer.用光电吸收计通过萘间苯二酚反应测定葡萄糖醛酸的研究。
Biochem J. 1944;38(3):274-9. doi: 10.1042/bj0380274.
2
STEREOCHEMICAL ASPECTS OF THE METABOLISM OF THE ISOMERIC METHYLCYCLOHEXANOLS AND METHYLCYCLOHEXANONES.异构甲基环己醇和甲基环己酮代谢的立体化学方面
Biochem J. 1965 Apr;95(1):59-69. doi: 10.1042/bj0950059.
3
Studies in detoxication. 79. The metabolism of cyclo [14C] hexane and its derivatives.解毒研究。79. 环[14C]己烷及其衍生物的代谢
Biochem J. 1959 Jun;72(2):193-200. doi: 10.1042/bj0720193.
4
The metabolism of cis- and trans-decalin.顺式和反式十氢化萘的代谢
Biochem J. 1966 Aug;100(2):403-6. doi: 10.1042/bj1000403.
5
Metabolism of methyldecalins.甲基十氢化萘的代谢
Biochem J. 1970 Sep;119(2):299-302. doi: 10.1042/bj1190299.
6
Metabolism of camphors and related compounds.樟脑及相关化合物的代谢
Biochem J. 1969 Jun;113(1):57-65. doi: 10.1042/bj1130057.
Zotero 插件