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宫颈涂片进行产前性别检测:利用Y体荧光法取得成功结果。

Prenatal sex detection with endocervical smears: successful results utilizing Y-bodyfluoroscence.

作者信息

Rhine S A, Cain J L, Cleary R E, Palmer C G, Thompson J F

出版信息

Am J Obstet Gynecol. 1975 May;122(2):155-60. doi: 10.1016/s0002-9378(16)33486-x.

DOI:10.1016/s0002-9378(16)33486-x
PMID:50740
Abstract

Highly equivocal results, regarding procedures for the prenatal detection of fetal sexls found in the endocervix, are reported in the literature dating from 1971. The far-reaching genetic and obstetric implications of such procedures led us to investigate endocervical smears from 36 patients (taken during all three trimesters) and study the validity and practicality of this test. Fetal sex was correctly predicted in 31 of 36cases and all 18 male predictions delivered males. In addition, many previously reported and newly found sources of error were encountered and evaluated. It is concludedthat there are indeed cells of fetal origin being shed into the endocervix and they canbe used as a reliable indicator of fetal sex in all three trimesters.

摘要

1971年以来的文献报道了关于宫颈内胎儿性别产前检测程序的高度模棱两可的结果。此类程序深远的遗传学和产科意义促使我们对36例患者(在所有三个孕期采集)的宫颈涂片进行研究,并探讨该检测的有效性和实用性。36例中有31例正确预测了胎儿性别,所有18例预测为男性的孕妇均分娩出男性胎儿。此外,我们还遇到并评估了许多先前报道和新发现的误差来源。结论是,确实有胎儿来源的细胞脱落至宫颈内,并且它们可作为所有三个孕期胎儿性别的可靠指标。

相似文献

1
Prenatal sex detection with endocervical smears: successful results utilizing Y-bodyfluoroscence.宫颈涂片进行产前性别检测:利用Y体荧光法取得成功结果。
Am J Obstet Gynecol. 1975 May;122(2):155-60. doi: 10.1016/s0002-9378(16)33486-x.
2
Unreliability of prenatal determination of fetal sex with the use of Y-body fluorescence in midcervical smears.利用宫颈中部涂片的Y体荧光进行产前胎儿性别鉴定的不可靠性。
Am J Obstet Gynecol. 1978 Feb 1;130(3):300-1.
3
Fluorescent Y bodies from endocervical smears for prenatal sex detection.用于产前性别检测的宫颈涂片荧光Y小体。
Ala J Med Sci. 1977 Oct;14(4):438.
4
Prenatal sex determination by endocervical smear. A new approach diagnosis.通过宫颈涂片进行产前性别鉴定。一种新的诊断方法。
Indian Pediatr. 1979 Aug;16(8):661-3.
5
Non-invasive early prenatal diagnosis using fluorescent in situ hybridization on transcervical cells: comparison of two different methods for retrieval.经宫颈细胞荧光原位杂交技术用于非侵入性早期产前诊断:两种不同取材方法的比较
Eur J Obstet Gynecol Reprod Biol. 2001 Mar;95(1):37-41. doi: 10.1016/s0301-2115(00)00357-2.
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[Are desquamated trophoblastic cells retrieved from the cervix suitable for a prenatal diagnosis?].从宫颈获取的脱落滋养层细胞是否适合用于产前诊断?
Contracept Fertil Sex. 1994 Jul-Aug;22(7-8):475-7.
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Prenatal sex determination by fluorescent staining of cells for the presence of Y chromatin.
Am J Obstet Gynecol. 1974 Jul 15;119(6):853-4. doi: 10.1016/0002-9378(74)90102-1.
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Prenatal sex determination by fluorescent staining of the cervical smear for the presence of a Y chromosome: an evaluation.
Am J Obstet Gynecol. 1973 Mar 15;115(6):866. doi: 10.1016/0002-9378(73)90541-3.
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Detection of fetal cells in endocervical samples.宫颈管样本中胎儿细胞的检测。
Ann N Y Acad Sci. 1994 Sep 7;731:186-92. doi: 10.1111/j.1749-6632.1994.tb55768.x.
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Detection of fetal Y-specific DNA from the cervix.从宫颈检测胎儿Y特异性DNA。
Acta Obstet Gynecol Scand. 1995 Apr;74(4):248-50. doi: 10.3109/00016349509024443.

引用本文的文献

1
Trophoblast retrieval and isolation from the cervix: origins of cervical trophoblasts and their potential value for risk assessment of ongoing pregnancies.从宫颈中获取和分离滋养层细胞:宫颈滋养层细胞的起源及其对正在进行的妊娠风险评估的潜在价值。
Hum Reprod Update. 2018 Jul 1;24(4):484-496. doi: 10.1093/humupd/dmy008.
2
Transcervical retrieval of fetal cells in the practice of modern medicine: a review of the current literature and future direction.经宫颈获取胎儿细胞在现代医学实践中的应用:对当前文献的回顾和未来方向。
Fertil Steril. 2010 Apr;93(6):1725-30. doi: 10.1016/j.fertnstert.2009.11.022. Epub 2010 Jan 13.
3
First trimester fetal karyotyping using chorionic villi: technical development and diagnostic application.
Experientia. 1986 Oct 15;42(10):1097-101. doi: 10.1007/BF01941283.