Rosenberg W, Schlager G, Gennaro J F
Anat Rec. 1979 Nov;195(3):511-24. doi: 10.1002/ar.1091950310.
An investigation was performed on a new strain of genetically hypertensive mice to study those aspects of the renal glomerulus which have in the past been implicated in the etiology of renal parenchymal hypertension. Morphometric analyses were carried out utilizing a computerized graphic data analysing system on information obtained through transmission electron microscopy. Chronically hypertensive animals exhibited thinner basement membranes with numerous sub-epithelial focal thickenings, which were largely absent from the normotensive controls. No difference was noted in the width of the epithelial slit pores (interpedicelar spaces). The glomerular capillary loops of the hypertensive animals appeared otherwise unremarkable, as did the urinary space and parietal epithelium of Bowman's capsule. No evidence of renal parenchymal pathologies implicated in the etiology of systemic hypertension was observed, therefore, these animals would seem to be suitable models for human essential hypertension.
对一种新的遗传性高血压小鼠品系进行了研究，以探讨过去被认为与肾实质性高血压病因有关的肾小球方面。利用计算机图形数据分析系统对通过透射电子显微镜获得的信息进行形态计量分析。慢性高血压动物的基底膜较薄，有许多上皮下局灶性增厚，而正常血压对照组基本没有。上皮裂孔（足突间间隙）的宽度没有差异。高血压动物的肾小球毛细血管袢以及肾小囊的尿空间和壁层上皮在其他方面看起来并无异常。未观察到与系统性高血压病因有关的肾实质病变证据，因此，这些动物似乎是人类原发性高血压的合适模型。
