Gregus Z, Fischer E
Arch Int Pharmacodyn Ther. 1979 Aug;240(2):180-92.
Hepatic uptake and biliary excretion of some exogenous organic anions administered simultaneously with sodium taurocholate (TC) have been investigated in anaesthetized (1.2 g/kg urethane i.p.) rats. TC (100 or 200 mumol/kg i.v.) significantly increased the biliary excretion of indocyanine green (ICG), bromcresol green (BCG), rose bengal (RB) and bromsulphthalein (BSP). The biliary excretion rates of eosine (EO) and bromsulphthalein-glutathione conjugate (BSP-GSH) were not affected by TC. However, simultaneously given TC significantly reduced the biliary excretion of amaranth (AM). The effect of TC on the biliary excretion rates of organic anions seems to depend on the properties of the anions investigated. ICG, BCG, RB and BSP depress bile production, inhibit mitochondrial respiration and are excreted at low rates. Biliary excretion of these anions was enhanced by TC. EO, BSP-GSH and AM had no depressing effect on the function of liver cells and showed higher excretory rates than the above-mentioned substances. The changes in biliary flow measured during excretion of drugs did not parallel the changes in biliary excretion rate. The hepatic uptake of all organic anions studied was depressed by TC. This finding indicates that no correlation exists between the effects of TC on hepatic uptake and biliary excretion of organic anions.
在麻醉（腹腔注射1.2 g/kg氨基甲酸乙酯）的大鼠中，研究了与牛磺胆酸钠（TC）同时给药的一些外源性有机阴离子的肝脏摄取和胆汁排泄情况。静脉注射100或200 μmol/kg的TC显著增加了吲哚菁绿（ICG）、溴甲酚绿（BCG）、孟加拉玫瑰红（RB）和溴磺酞（BSP）的胆汁排泄。曙红（EO）和溴磺酞-谷胱甘肽共轭物（BSP-GSH）的胆汁排泄率不受TC影响。然而，同时给予TC显著降低了苋菜红（AM）的胆汁排泄。TC对有机阴离子胆汁排泄率的影响似乎取决于所研究阴离子的性质。ICG、BCG、RB和BSP抑制胆汁生成，抑制线粒体呼吸，且排泄率较低。TC增强了这些阴离子的胆汁排泄。EO、BSP-GSH和AM对肝细胞功能没有抑制作用，且排泄率高于上述物质。药物排泄过程中测得的胆汁流量变化与胆汁排泄率变化不平行。TC抑制了所有研究的有机阴离子的肝脏摄取。这一发现表明，TC对有机阴离子肝脏摄取和胆汁排泄的影响之间不存在相关性。
