Gregus Z, Fischer E, Varga F
Arch Int Pharmacodyn Ther. 1980 Jun;245(2):311-22.
Four hours after oral administration of cholestyramine (1.0 g/kg) the biliary output of bile acids decreased to 21 per cent of the control value. The biliary excretion of indocyanine green (ICG; 15--60 mumol/kg i.v.), rose bengal (RB; 15--60 mumol/kg i.v.), bromsulphthalein (BSP; 15--60 mumol/kg i.v.), bromcresol green (BCG;15--60 mumol/kg i.v.) and eosine (EO; 30--120 mumol/kg i.v.) was considerably depressed by cholestyramine pretreatment. The extent and duration of the reduction in the biliary excretion of organic anions in response to bile acid depletion were found to increase with their doses. In contrast, the biliary excretion rates of bromsulphthalein-glutathione conjugate (BSP-GSH; 60--240 mumol/kg i.v.) and amaranth (AM; 60--240 mumol/kg i.v.) remained unchanged following bile acid depletion. The hepatic uptake of the cholephilic agents investigated was not affected by bile acid depletion. It is concluded that the biliary excretion rates of ICG, RB, BSP, BCG and EO are dependent on the excretion rates of endogenous bile acids. The hepatic transport rates of BSP-GSH and AM, however, seem to be relatively insensitive to the biliary output of endogenous bile salts.
口服消胆胺（1.0克/千克）4小时后，胆汁酸的胆汁排出量降至对照值的21%。消胆胺预处理使静脉注射的吲哚菁绿（ICG；15 - 60微摩尔/千克）、孟加拉玫瑰红（RB；15 - 60微摩尔/千克）、磺溴酞钠（BSP；15 - 60微摩尔/千克）、溴甲酚绿（BCG；15 - 60微摩尔/千克）和伊红（EO；30 - 120微摩尔/千克）的胆汁排泄量显著降低。发现随着剂量增加，胆汁酸耗竭后有机阴离子胆汁排泄减少的程度和持续时间会增加。相比之下，胆汁酸耗竭后，磺溴酞钠 - 谷胱甘肽共轭物（BSP - GSH；60 - 240微摩尔/千克静脉注射）和苋菜红（AM；60 - 240微摩尔/千克静脉注射）的胆汁排泄率保持不变。所研究的亲胆剂的肝脏摄取不受胆汁酸耗竭的影响。结论是，ICG、RB、BSP、BCG和EO的胆汁排泄率取决于内源性胆汁酸的排泄率。然而，BSP - GSH和AM的肝脏转运率似乎对内源性胆汁盐的胆汁排出量相对不敏感。
