发育中大鼠脑匀浆中3-羟基-3-甲基戊二酰辅酶A还原酶的激活
Activation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in homogenates of developing rat brain.
作者信息
Maltese W A, Volpe J J
出版信息
Biochem J. 1979 Aug 15;182(2):367-70. doi: 10.1042/bj1820367.
Abstract
The specific activity of 3-hydroxy-3-methylglutaryl-CoA reductase increases when homogenates of developing rat brain are incubated at 37 degrees C or kept on ice. This increase is completely blocked by the addition of F- to the homogenization medium and the assay mixture. The capacity for activation of the reductase is greatest during the early postnatal period and declines as brain maturation proceeds. The data suggest that catalytic modification of the reductase may play a role in the regulation of cholesterol synthesis in the developing brain.
摘要
当将发育中大鼠脑的匀浆在37℃孵育或置于冰上时，3-羟基-3-甲基戊二酰辅酶A还原酶的比活性会增加。向匀浆介质和测定混合物中添加氟化物会完全阻断这种增加。还原酶的激活能力在出生后早期最大，并随着脑成熟的进行而下降。数据表明，还原酶的催化修饰可能在发育中脑的胆固醇合成调节中起作用。
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