成年大鼠和7日龄大鼠大脑中3-羟基-3-甲基戊二酰辅酶A还原酶的活性
Activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in brains of adult and 7-day-old rats.
作者信息
Sudjic M M, Booth R
出版信息
Biochem J. 1976 Feb 15;154(2):559-60. doi: 10.1042/bj1540559.
Abstract
Rat brain contains 3-hydroxy-3-methylglutaryl-CoA reductase activity, but this enzyme is far more active in 7-day-old brain than in adult brain. This difference may partly explain why cholesterol biosynthesis is more rapid in growing than in adult rat brain.
摘要
大鼠大脑含有3-羟基-3-甲基戊二酰辅酶A还原酶活性，但这种酶在7日龄大脑中的活性远比在成年大脑中高。这种差异可能部分解释了为什么在生长中的大鼠大脑中胆固醇生物合成比成年大鼠大脑中更快。
相似文献
1
Activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in brains of adult and 7-day-old rats.成年大鼠和7日龄大鼠大脑中3-羟基-3-甲基戊二酰辅酶A还原酶的活性
Biochem J. 1976 Feb 15;154(2):559-60. doi: 10.1042/bj1540559.
2
A new method for assaying rat liver microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and its application in a study of the effect of dietary cholesterol on this effect of dietary cholesterol on this enzyme.一种测定大鼠肝脏微粒体3-羟基-3-甲基戊二酰辅酶A还原酶活性的新方法及其在膳食胆固醇对该酶影响研究中的应用。
Biochem J. 1977 Jun 15;164(3):501-8. doi: 10.1042/bj1640501.
3
The effect of dietary cholesterol on rat liver microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity.膳食胆固醇对大鼠肝脏微粒体3-羟基-3-甲基戊二酰辅酶A还原酶活性的影响。
Biochem Soc Trans. 1977;5(1):294. doi: 10.1042/bst0050294.
4
5
Effect of lipoprotein on 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase activity in rat liver cell culture: special suppressant effect of a lipoprotein isolated from hypercholesterolemic rat plasma.
Biochem Biophys Res Commun. 1975 Nov 3;67(1):119-25. doi: 10.1016/0006-291x(75)90291-0.
6
Dog liver 3-hydroxy-3-methylglutaryl coenzyme A reductase.狗肝脏3-羟基-3-甲基戊二酰辅酶A还原酶。
Enzyme. 1977;22(4):242-8.
7
Evidence for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in nonhepatic tissues of rat.大鼠非肝脏组织中3-羟基-3-甲基戊二酰辅酶A还原酶活性及胆固醇合成调控的证据。
Proc Natl Acad Sci U S A. 1976 Aug;73(8):2564-8. doi: 10.1073/pnas.73.8.2564.
8
The influence of catecholamines and cyclic AMP on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and lipid biosynthesis in isolated rat hepatocytes.
Arch Biochem Biophys. 1975 Sep;170(1):188-203. doi: 10.1016/0003-9861(75)90110-1.
9
Hepatic 3-hydroxy-3-methylglutaryl CoA reductase activity in germfree rats.无菌大鼠肝脏中3-羟基-3-甲基戊二酰辅酶A还原酶活性
Proc Soc Exp Biol Med. 1977 Mar;154(3):319-21. doi: 10.3181/00379727-154-39662.
10
Regulation of rat liver beta-hydroxy-beta-methylglutaryl coenzyme. A reductase activity and cholesterol levels of serum and liver in various dietary and hormonal states.不同饮食和激素状态下大鼠肝脏β-羟基-β-甲基戊二酰辅酶A还原酶活性以及血清和肝脏胆固醇水平的调节
Arch Biochem Biophys. 1975 May;168(1):89-95. doi: 10.1016/0003-9861(75)90231-3.
引用本文的文献
1
Changes in sterol biosynthesis accompanying cessation of glial cell growth in serum-free medium.无血清培养基中神经胶质细胞生长停止时甾醇生物合成的变化。
Biochem J. 1980 Nov 15;192(2):709-17. doi: 10.1042/bj1920709.
2
3-Hydroxy-3-methylglutaryl-coenzyme A reductase in normal and dystrophic hamsters.正常和营养不良仓鼠体内的3-羟基-3-甲基戊二酰辅酶A还原酶
Biochem J. 1982 Mar 1;201(3):501-4. doi: 10.1042/bj2010501.
3
Relationship between changes in free cholesterol and pyrophosphomevalonate decarboxylase activity during myelination.
Neurochem Res. 1983 Jun;8(6):711-21. doi: 10.1007/BF00964728.
4
Cytosolic 3-hydroxy-3-methyl glutaryl coenzyme a synthase in rat brain: properties and developmental change.大鼠脑中的胞质3-羟基-3-甲基戊二酰辅酶A合酶：特性与发育变化
Neurochem Res. 1982 Nov;7(11):1359-66. doi: 10.1007/BF00966064.
5
Activation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in homogenates of developing rat brain.发育中大鼠脑匀浆中3-羟基-3-甲基戊二酰辅酶A还原酶的激活
Biochem J. 1979 Aug 15;182(2):367-70. doi: 10.1042/bj1820367.
6
Acetoacetate metabolism in rat brain. Development of acetoacetyl-coenzyme A deacylase and 3-hydroxy-3-methylglutaryl-coenzyme A synthase.大鼠脑中乙酰乙酸的代谢。乙酰乙酰辅酶A脱酰酶和3-羟基-3-甲基戊二酰辅酶A合酶的发育。
Biochem J. 1978 Dec 15;176(3):951-8. doi: 10.1042/bj1760951.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Incorporation of C14 of acetate-1-C14 and pyruvate-2-C14 into brain cholesterol in the intact rat.在完整大鼠体内，将乙酸盐 -1-C14 和丙酮酸盐 -2-C14 的 C14 掺入脑胆固醇中。
Proc Soc Exp Biol Med. 1957 Dec;96(3):738-40. doi: 10.3181/00379727-96-23593.
3
Regulation of sterol synthesis in developing brains of normal and jimpy mice.正常小鼠和jimpy小鼠发育中大脑的固醇合成调节
Arch Biochem Biophys. 1969 Dec;135(1):201-8. doi: 10.1016/0003-9861(69)90531-1.
4
Vulnerable periods of brain development. In: lipids, malnutrition & the developing brain.
Ciba Found Symp. 1971:9-29.
5
Diurnal variations in rat liver 3-hydroxy-3-methylglutaryl-Coenzyme A reductase activity in relation to feeding.大鼠肝脏3-羟基-3-甲基戊二酰辅酶A还原酶活性的昼夜变化与进食的关系
Biochem J. 1972 Dec;130(4):1163-5. doi: 10.1042/bj1301163.
Zotero 插件