Significance of azathioprine metabolites.
作者信息
Elion G B
出版信息
Proc R Soc Med. 1972 Mar;65(3):257-60. doi: 10.1177/003591577206500315.
Abstract
摘要
相似文献
1
Significance of azathioprine metabolites.硫唑嘌呤代谢物的意义。
Proc R Soc Med. 1972 Mar;65(3):257-60. doi: 10.1177/003591577206500315.
2
Serum immunosuppressive activity of azathioprine in normal subjects and patients with liver diseases.硫唑嘌呤在正常受试者和肝病患者中的血清免疫抑制活性。
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HPLC analysis of azathioprine metabolites in red blood cells, plasma and urine in renal transplant recipients.肾移植受者红细胞、血浆和尿液中硫唑嘌呤代谢物的高效液相色谱分析。
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[Determination of active metabolites of immunosuppressive agents in the serum. Application to azathioprine].[血清中免疫抑制剂活性代谢物的测定。在硫唑嘌呤中的应用]
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5
Demonstration of enzymatic activity converting azathioprine to 6-mercaptopurine.将硫唑嘌呤转化为6-巯基嘌呤的酶活性的证明。
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6
The metabolic fate of the methylnitroimidazole moiety of azathioprine in the rat.硫唑嘌呤的甲基硝基咪唑部分在大鼠体内的代谢命运。
J Pharmacol Exp Ther. 1973 Dec;187(3):588-601.
7
Pharmacokinetics of azathioprine and 6-mercaptopurine: methodological aspects and preliminary results in uremic patients.硫唑嘌呤和6-巯基嘌呤的药代动力学：方法学方面及尿毒症患者的初步结果
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8
Conversion of azathioprine into mercaptopurine and mercaptoimidazole derivatives in vitro and during immunosuppressive therapy.硫唑嘌呤在体外及免疫抑制治疗期间转化为巯嘌呤和巯基咪唑衍生物。
Aust J Exp Biol Med Sci. 1967 Dec;45(6):681-91. doi: 10.1038/icb.1967.68.
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Inhibition of hepatic metabolism of azathioprine in vivo.体内硫唑嘌呤肝脏代谢的抑制作用。
Gastroenterology. 1978 Jan;74(1):90-2.
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Pharmacologically active metabolites of drugs and other foreign compounds. Clinical, pharmacological, therapeutic and toxicological considerations.药物及其他外来化合物的药理活性代谢产物。临床、药理、治疗及毒理学考量。
Drugs. 1982 Dec;24(6):519-42. doi: 10.2165/00003495-198224060-00003.
6
Immunosuppressive activity in patients with active chronic hepatitis and primary biliary cirrhosis treated with azathioprine.接受硫唑嘌呤治疗的活动性慢性肝炎和原发性胆汁性肝硬化患者的免疫抑制活性。
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Liver disease in childhood: principles of management.儿童肝病：管理原则
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Induction of uterine hemangioendothelioma and lymphoma in (C57BL/6N x C3H/2N)F1 mice by oral administration of azathioprine.通过口服硫唑嘌呤在（C57BL/6N×C3H/2N）F1小鼠中诱导子宫血管内皮瘤和淋巴瘤。
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The clinical pharmacology of 6-mercaptopurine.6-巯基嘌呤的临床药理学。
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Problems with immunosuppressive agents in renal disease.肾病中免疫抑制剂的问题。
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本文引用的文献
1
The fate of 6-mercaptopurine in man.6-巯基嘌呤在人体内的代谢情况。
Ann N Y Acad Sci. 1954 Dec 6;60(2):304-14. doi: 10.1111/j.1749-6632.1954.tb40021.x.
2
The fate of 6-mercaptopurine in mice.6-巯基嘌呤在小鼠体内的代谢情况
Ann N Y Acad Sci. 1954 Dec 6;60(2):297-303. doi: 10.1111/j.1749-6632.1954.tb40020.x.
3
RELATIONSHIP BETWEEN METABOLIC FATES AND ANTITUMOR ACTIVITIES OF THIOPURINES.硫嘌呤的代谢命运与抗肿瘤活性之间的关系
Cancer Res. 1963 Sep;23:1207-17.
4
Experimental, clinical, and metabolic studies of thiopurines.硫唑嘌呤的实验、临床及代谢研究
Cancer Chemother Rep. 1962 Feb;16:197-202.
5
In vitro evaluation of immunosuppressive drugs.免疫抑制药物的体外评估。
Nature. 1969 Jun 7;222(5197):998-9. doi: 10.1038/222998a0.
6
Symposium on immunosuppressive drugs. Biochemistry and pharmacology of purine analogues.免疫抑制药物研讨会。嘌呤类似物的生物化学与药理学
Fed Proc. 1967 May-Jun;26(3):898-904.
7
[Studies on the metabolism of azathioprine].[硫唑嘌呤的代谢研究]
C R Acad Hebd Seances Acad Sci D. 1970 Jul 27;271(4):453-6.
8
Serum immunosuppressive activity due to azathioprine and its relation to hepatic function after liver transplantation.
Lancet. 1970 Jun 6;1(7658):1196-9. doi: 10.1016/s0140-6736(70)91786-1.
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