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Pharmacologically active metabolites of drugs and other foreign compounds. Clinical, pharmacological, therapeutic and toxicological considerations.

作者信息

Drayer D E

出版信息

Drugs. 1982 Dec;24(6):519-42. doi: 10.2165/00003495-198224060-00003.

DOI:10.2165/00003495-198224060-00003
PMID:6759093
Abstract
摘要

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Drugs. 1982 Dec;24(6):519-42. doi: 10.2165/00003495-198224060-00003.
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The relative value of synthetic quinidine, dihydroquinidine, commercial quinidine, and quinine in the control of cardiac arrhythmias.
J Pharmacol Exp Ther. 1947 Jul;90(3):191-201.
2
A STUDY OF THE PRODUCT OF DEMETHYLATION OF TRIMETHADIONE IN THE CONTROL OF PETIT MAL EPILEPSY.三甲双酮脱甲基产物治疗小儿癫痫的研究
Neurology. 1965 May;15:449-54. doi: 10.1212/wnl.15.5.449.
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CONGENITAL ANOMALIES PROBABLY INDUCED BY CYCLOPHOSPHAMIDE.可能由环磷酰胺诱发的先天性异常。
JAMA. 1964 May 4;188:423-6. doi: 10.1001/jama.1964.03060310023005.
4
The role of metabolism in the immunogenicity of drugs: production of antibodies to a horseradish peroxidase generated conjugate paracetamol.代谢在药物免疫原性中的作用：针对辣根过氧化物酶生成的对乙酰氨基酚缀合物产生抗体。
Clin Exp Immunol. 1985 Aug;61(2):224-31.
5
Formation of active metabolites of psychotropic drugs. An updated review of their significance.精神药物活性代谢产物的形成。对其重要性的最新综述。
Clin Pharmacokinet. 1990 Jun;18(6):434-59. doi: 10.2165/00003088-199018060-00002.
6
The role of metabolites in bioequivalency assessment. I. Linear pharmacokinetics without first-pass effect.代谢物在生物等效性评估中的作用。I. 无首过效应的线性药代动力学。
Pharm Res. 1991 Jan;8(1):25-32. doi: 10.1023/a:1015865920043.
4
Carcinogenicity of 2-naphthylhydroxylamine and 2-naphthylamine.2-萘羟胺和2-萘胺的致癌性。
Br J Cancer. 1963 Mar;17(1):79-84. doi: 10.1038/bjc.1963.12.
5
A study of the German outbreak of phocomelia. The thalidomide syndrome.一项关于德国短肢畸形爆发的研究。沙利度胺综合征。
JAMA. 1962 Jun 30;180:1106-14.
6
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Neurology. 1958 Apr;8(Suppl 1):106-12. doi: 10.1212/wnl.8.suppl_1.106.
7
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J Pharmacol Exp Ther. 1958 May;123(1):63-9.
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A comparative evaluation of the hypnotic potency of chloral hydrate and trichloroethanol. I. Studies at the Johns Hopkins University School of Medicine. II. Studies at the St. Louis University School of Medicine. III. Studies at Harvard Medical School.
Bull Johns Hopkins Hosp. 1955 Feb;96(2):71-83.
9
Measurement of benzo(a)pyrene-DNA adducts by enzyme immunoassays and radioimmunoassay.通过酶免疫测定法和放射免疫测定法测量苯并(a)芘-DNA加合物。
Cancer Res. 1981 Mar;41(3):1091-5.
10
Polycyclic aromatic hydrocarbons: a review.
J Environ Pathol Toxicol. 1980 Jun-Jul;3(5-6):537-67.