Reza M J, Dornfeld L, Goldberg L S
Arthritis Rheum. 1975 Jul-Aug;18(4):335-8. doi: 10.1002/art.1780180407.
Seven hypertensive patients with idiopathic systemic lupus erythematosus were treated with hydralazine. They received a mean daily dose of 203 mg for a mean duration of 21 months. All were taking prednisone alone or in combination with azathioprine. During therapy with hydralazine, there were no new symptoms nor exacerbation of pre-existing symptoms attributable to systemic lupus. Laboratory parameters, including antinuclear antibody titers and complement levels, either improved or remained stable. The results indicate that hydralazine can be safely used in hypertensive patients with systemic lupus who are receiving concomitant immunosuppressive therapy.
七名患有特发性系统性红斑狼疮的高血压患者接受了肼屈嗪治疗。他们平均每日剂量为203毫克，平均疗程为21个月。所有人都单独服用泼尼松或与硫唑嘌呤联合使用。在使用肼屈嗪治疗期间，没有出现可归因于系统性红斑狼疮的新症状或原有症状加重。包括抗核抗体滴度和补体水平在内的实验室参数有所改善或保持稳定。结果表明，肼屈嗪可安全用于正在接受免疫抑制治疗的系统性红斑狼疮高血压患者。
