仓鼠小肠中胆碱的代谢与转运
Metabolism and transfer of choline in hamster small intestine.
作者信息
Flower R J, Pollitt R J, Sanford P A, Smyth D H
出版信息
J Physiol. 1972 Oct;226(2):473-89. doi: 10.1113/jphysiol.1972.sp009994.
Abstract
- The transfer and metabolism of choline was studied with sacs of everted intestine of hamster.2. Approximately half the choline transferred from the mucosal fluid may be metabolized. High voltage electrophoresis, paper chromatography and ion exchange chromatography have been used to identify this meta bolite as betaine.3. The concentration of choline and betaine together accumulating in the gut wall and serosal fluid are greater than that of choline present initially in the mucosal fluid indicating some kind of specific mechanism for choline transport.4. A detailed analysis of choline transfer suggests that the movement of choline cannot be accounted for by simple diffusion. The concentration of choline accumulating in the gut wall and serosal fluid, the inhibitory effects of hemicholinium-3 and alpha-methylglucoside on choline transfer, and the insensitivity of betaine transfer to hemicholinium-3 suggest a specific active transport process for choline independent of active betaine transport.
摘要
利用仓鼠外翻肠囊研究了胆碱的转运与代谢。
从黏膜液中转运来的胆碱约有一半可能会被代谢。已使用高压电泳、纸层析和离子交换层析法将这种代谢产物鉴定为甜菜碱。
积聚在肠壁和浆膜液中的胆碱和甜菜碱的总浓度高于最初存在于黏膜液中的胆碱浓度，这表明胆碱的转运存在某种特定机制。
对胆碱转运的详细分析表明，胆碱的移动不能用简单扩散来解释。积聚在肠壁和浆膜液中的胆碱浓度、半胱氨酸-3和α-甲基葡萄糖苷对胆碱转运的抑制作用，以及甜菜碱转运对半胱氨酸-3的不敏感性，表明胆碱存在一种独立于甜菜碱主动转运的特定主动转运过程。
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