癌胚抗原与“非特异性交叉反应抗原”（NCA和NCA 2）之间的抗原交叉反应性研究。
Study of the antigenic cross reactivity between carcinoembryonic antigen and "nonspecific cross reacting antigens" (NCA and NCA 2).
作者信息
Neveu T, Staebler D, Chavanel G, Burtin P
出版信息
Br J Cancer. 1975 May;31(5):524-7. doi: 10.1038/bjc.1975.92.
Abstract
The immunochemical relationship between CEA, NCA and NCA 2 was studied in guinea-pigs. Strong cross reactions were found between these antigens, either in delayed or anaphylactic reactions. Some specific determinants for each antigen could still be demonstrated. Delayed hypersensitivity is likely to be due to the protein moiety of the molecules while anaphylactic reactivity could probably be related to their glucidic parts. Consequently, CEA and NCA have common antigenic determinants on their glucidic and peptidic moieties, perhaps more on the latter ones.
摘要
在豚鼠中研究了癌胚抗原（CEA）、非癌胚抗原（NCA）和NCA 2之间的免疫化学关系。在迟发型或过敏反应中，这些抗原之间均发现强烈的交叉反应。每种抗原的一些特异性决定簇仍可被证实。迟发型超敏反应可能归因于分子的蛋白质部分，而过敏反应性可能与其糖部分有关。因此，CEA和NCA在其糖部分和肽部分具有共同的抗原决定簇，可能在后者上更多。
相似文献
1
Study of the antigenic cross reactivity between carcinoembryonic antigen and "nonspecific cross reacting antigens" (NCA and NCA 2).癌胚抗原与“非特异性交叉反应抗原”（NCA和NCA 2）之间的抗原交叉反应性研究。
Br J Cancer. 1975 May;31(5):524-7. doi: 10.1038/bjc.1975.92.
2
3
4
Reaction profiles of seven enzyme immunoassay kits for carcinoembryonic antigen (CEA) analyzed with purified preparations of CEA and related normal antigens.使用癌胚抗原（CEA）及相关正常抗原的纯化制剂分析七种癌胚抗原酶免疫测定试剂盒的反应曲线。
Clin Biochem. 1992 Feb;25(1):29-35. doi: 10.1016/0009-9120(92)80042-f.
5
Immunochemical identification of an alpha 1-acid glycoprotein-antigenic determinant on carcinoembryonic antigen (CEA) and non-specific cross-reacting antigen (NCA).癌胚抗原（CEA）和非特异性交叉反应抗原（NCA）上α1-酸性糖蛋白抗原决定簇的免疫化学鉴定。
Clin Chim Acta. 1984 Mar 27;138(1):9-19. doi: 10.1016/0009-8981(84)90349-8.
6
[Antigenic structures of CEA and CEA-related normal antigens and problems related to the determination of blood CEA concentrations].[癌胚抗原及癌胚抗原相关正常抗原的抗原结构与血癌胚抗原浓度测定相关问题]
Gan To Kagaku Ryoho. 1983 Feb;10(2 Pt 2):575-84.
7
8
Antigenic reactivities of purified preparations of carcinoembryonic antigen (CEA) and related normal antigens using four different radioimmunoassay systems for CEA.使用四种不同的癌胚抗原（CEA）放射免疫分析系统对纯化的癌胚抗原（CEA）制剂及相关正常抗原进行抗原反应性检测。
J Immunol Methods. 1983 May 27;60(1-2):221-33. doi: 10.1016/0022-1759(83)90350-2.
9
Purification and characterization of a 50,000 mol. wt glycoprotein antigen, and localization of determinants involved in cross-reactivity with carcinoembryonic antigen.一种分子量为50,000的糖蛋白抗原的纯化与特性分析，以及与癌胚抗原交叉反应相关决定簇的定位
Mol Immunol. 1983 Apr;20(4):421-31. doi: 10.1016/0161-5890(83)90023-8.
引用本文的文献
1
Studies on the structure and immunological activity of carcinoembryonic antigen - the role of disulphide bonds.癌胚抗原的结构与免疫活性研究——二硫键的作用
Br J Cancer. 1975 Dec;32(6):708-19. doi: 10.1038/bjc.1975.282.
本文引用的文献
1
[Studies on hypersensitivity. V. Analysis of various types of hypersensitivity induced by the injection of an immune complex in complete adjuvants].[超敏反应研究。V. 对在完全佐剂中注射免疫复合物诱导的各类超敏反应的分析]
Ann Inst Pasteur (Paris). 1966 Oct;111(4):377-412.
2
Immunologic responses of guinea pigs to dextran.豚鼠对葡聚糖的免疫反应。
J Immunol. 1968 Aug;101(2):203-9.
3
Inhibition of macrophage migration by a skin-reactive polysaccharide from BCG culture filtrates.卡介苗培养滤液中一种皮肤反应性多糖对巨噬细胞迁移的抑制作用。
J Immunol. 1969 Jun;102(6):1466-73.
4
Preparation and isolation of immunologically active glycopeptides from carcinoembryonic antigen (CEA).从癌胚抗原（CEA）中制备和分离具有免疫活性的糖肽。
Int J Cancer. 1974 Feb 15;13(2):151-63. doi: 10.1002/ijc.2910130202.
5
Introduction of cellular immunity to a chemically altered tumor antigen.将细胞免疫引入化学改变的肿瘤抗原
J Immunol. 1973 Dec;111(6):1800-3.
6
Polysaccharide in delayed hypersensitivity. I. Pneumococcal polysaccharide as inducer and elicitor of delayed reactivity in guinea pigs.迟发型超敏反应中的多糖。I. 肺炎球菌多糖作为豚鼠迟发型反应的诱导剂和激发剂。
J Exp Med. 1970 Jan 1;131(1):189-206. doi: 10.1084/jem.131.1.189.
7
Characterization of a second normal antigen that cross-reacts with CEA.一种与癌胚抗原发生交叉反应的第二种正常抗原的特性分析。
J Immunol. 1973 Dec;111(6):1926-8.
8
Delayed hypersensitivity and polysaccharide-containing antigens.迟发型超敏反应与含多糖抗原
Br Med Bull. 1967 Jan;23(1):72-5. doi: 10.1093/oxfordjournals.bmb.a070520.
9
Immunological study of carcinoembryonic antigen (CEA) and a related glycoprotein.癌胚抗原（CEA）及一种相关糖蛋白的免疫学研究。
Br J Cancer. 1973 Aug;28(2):147-60. doi: 10.1038/bjc.1973.132.
10
Studies on vascular permeability. I. Description and evaluation of methods.血管通透性研究。I. 方法的描述与评估。
Br J Exp Pathol. 1973 Feb;54(1):20-8.
Zotero 插件