迟发型超敏反应中的多糖。I. 肺炎球菌多糖作为豚鼠迟发型反应的诱导剂和激发剂。
Polysaccharide in delayed hypersensitivity. I. Pneumococcal polysaccharide as inducer and elicitor of delayed reactivity in guinea pigs.
作者信息
Gerety R J, Ferraresi R W, Raffel S
出版信息
J Exp Med. 1970 Jan 1;131(1):189-206. doi: 10.1084/jem.131.1.189.
Abstract
A highly purified pneumococcal polysaccharide (Type II SSS) is a very efficient inducer of delayed hypersensitivity in random-bred guinea pigs. The cellular reactivity induced by this polysaccharide administered subcutaneously in complete Freund's adjuvant is of "tuberculin type"; it increases in intensity with time after the sensitizing injection, as judged by skin tests, the macrophage inhibition reaction and transfer of reactivity by peritoneal exudate cells. By contrast, the cellular reactivity induced by this immunogen in the absence of mycobacterial adjuvant has the characteristics of "Jones-Mote" reactivity. It is best seen at about 1 wk after sensitization; the reactions are characteristically little indurated and show histologic differences from tuberculin type responses; and the reactive state begins to disappear by 2-3 wk, with the accession of Arthus reactivity. This type of delayed reactivity may be related to an early phase of antibody synthesis.
摘要
高度纯化的肺炎球菌多糖（II型SSS）是随机繁殖豚鼠迟发型超敏反应的高效诱导剂。在完全弗氏佐剂中皮下注射这种多糖所诱导的细胞反应性属于“结核菌素型”；通过皮肤试验、巨噬细胞抑制反应以及腹膜渗出细胞的反应性转移判断，致敏注射后其强度随时间增加。相比之下，在没有分枝杆菌佐剂的情况下，这种免疫原诱导的细胞反应性具有“琼斯 - 莫特”反应性的特征。致敏后约1周时最明显；反应的特征是硬结很少，并显示出与结核菌素型反应的组织学差异；随着阿瑟斯反应的出现，反应状态在2 - 3周时开始消失。这种迟发型反应可能与抗体合成的早期阶段有关。
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