某些实验动物肿瘤中腺苷脱氨酶的水平以及腺苷脱氨酶抑制剂2-脱氧助间型霉素的可能治疗效果。
Levels of adenosine deaminase in some experimental animal tumours and the possible therapeutic effect of the ADA inhibitor 2-deoxy-coformycin.
作者信息
Hall J G, Gyure L, Peppard J, Orlans E
出版信息
Br J Cancer. 1979 Nov;40(5):750-4. doi: 10.1038/bjc.1979.256.
Abstract
The intracellular adenosine deaminase activities (ADA) in 12 different experimental animal tumours were measured. Unlike the leukaemic lymphoblasts of man, those of two spontaneous rat leukaemias did not have elevated levels of the enzyme. Very high levels were found in a rat plasma-cell tumour (IR 461) and an attempt was made to treat such tumours with the specific enzyme inhibitor, 2-deoxy-coformycin. The shortage of this drug prevented a systematic study, but a daily dose of 8 mg/kg had a significant inhibitory effect on the growth of tumours.
摘要
测定了12种不同实验动物肿瘤中的细胞内腺苷脱氨酶活性（ADA）。与人类白血病淋巴母细胞不同，两种自发性大鼠白血病的淋巴母细胞中该酶水平并未升高。在一种大鼠浆细胞瘤（IR 461）中发现该酶水平非常高，并尝试用特异性酶抑制剂2-脱氧助间型霉素治疗此类肿瘤。该药物的短缺妨碍了系统性研究，但每日8mg/kg的剂量对肿瘤生长有显著抑制作用。
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本文引用的文献
1
The deaminases of adenosine and adenylic acid in blood and tissues.血液和组织中腺苷及腺苷酸的脱氨酶
Biochem J. 1939 Apr;33(4):479-92. doi: 10.1042/bj0330479.
2
Serum adenosine deaminase: methodology and clinical applications.血清腺苷脱氨酶：方法学与临床应用
Clin Chem. 1962 Apr;8:133-40.
3
A STUDY OF THE TISSUE DISTRIBUTION OF ADENOSINE DEAMINASE IN SIX MAMMAL SPECIES.六种哺乳动物腺苷脱氨酶的组织分布研究
Comp Biochem Physiol. 1965 Jan;14:101-20. doi: 10.1016/0010-406x(65)90011-3.
4
Adenosine deaminase activity in lymphoid cells during antibody production.抗体产生过程中淋巴细胞中的腺苷脱氨酶活性。
Aust J Exp Biol Med Sci. 1963 Feb;41:93-7. doi: 10.1038/icb.1963.8.
5
Serum adenosine deaminase activity in cancer.
Proc Soc Exp Biol Med. 1959 Jul;101(3):560-2. doi: 10.3181/00379727-101-25015.
6
Plasma adenosine deaminase activity in tumour cases.
Biokhimiia. 1957 Jan-Feb;22(1-2):118-21.
7
The nature of the cytotoxic cells in lymph following primary antigenic challenge.初次抗原刺激后淋巴中细胞毒性细胞的性质。
Transplantation. 1969 Mar;7(3):194-203. doi: 10.1097/00007890-196903000-00006.
8
Influence of tumour growth on the evolution of cytotoxic lymphoid cells in rats bearing a spontaneously metastasizing syngeneic fibrosarcoma.
Br J Cancer. 1973 Aug;28(2):136-46. doi: 10.1038/bjc.1973.131.
9
Transplantable immunoglobulin-secreting tumours in rats. I. General features of LOU-Ws1 strain rat immunocytomas and their monoclonal proteins.大鼠可移植性免疫球蛋白分泌肿瘤。I. LOU-Ws1品系大鼠免疫细胞瘤及其单克隆蛋白的一般特征。
Int J Cancer. 1972 Nov;10(3):568-80. doi: 10.1002/ijc.2910100316.
10
Adenosine-deaminase deficiency and combined immunodeficiency syndrome.腺苷脱氨酶缺乏与联合免疫缺陷综合征
Lancet. 1972 Dec 16;2(7790):1316. doi: 10.1016/s0140-6736(72)92692-x.
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