某些实验动物肿瘤中腺苷脱氨酶的水平以及腺苷脱氨酶抑制剂2-脱氧助间型霉素的可能治疗效果。
Levels of adenosine deaminase in some experimental animal tumours and the possible therapeutic effect of the ADA inhibitor 2-deoxy-coformycin.
作者信息
Hall J G, Gyure L, Peppard J, Orlans E
出版信息
Br J Cancer. 1979 Nov;40(5):750-4. doi: 10.1038/bjc.1979.256.
Abstract
The intracellular adenosine deaminase activities (ADA) in 12 different experimental animal tumours were measured. Unlike the leukaemic lymphoblasts of man, those of two spontaneous rat leukaemias did not have elevated levels of the enzyme. Very high levels were found in a rat plasma-cell tumour (IR 461) and an attempt was made to treat such tumours with the specific enzyme inhibitor, 2-deoxy-coformycin. The shortage of this drug prevented a systematic study, but a daily dose of 8 mg/kg had a significant inhibitory effect on the growth of tumours.
摘要
测定了12种不同实验动物肿瘤中的细胞内腺苷脱氨酶活性（ADA）。与人类白血病淋巴母细胞不同，两种自发性大鼠白血病的淋巴母细胞中该酶水平并未升高。在一种大鼠浆细胞瘤（IR 461）中发现该酶水平非常高，并尝试用特异性酶抑制剂2-脱氧助间型霉素治疗此类肿瘤。该药物的短缺妨碍了系统性研究，但每日8mg/kg的剂量对肿瘤生长有显著抑制作用。
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