腺苷脱氨酶抑制作用的研究
Study on the inhibition of adenosine deaminase.
作者信息
Montgomery J A, Thomas H J, Zell A L, Einsphar H M, Bugg C E
出版信息
J Med Chem. 1985 Nov;28(11):1751-3. doi: 10.1021/jm00149a037.
PMID:4068002
Abstract
4(R)-(1-Hydroxyethyl)-5-methyl-1-beta-D-ribofuranosylimidazole (10), which contains only the asymmetric alcohol center of the diazepinol ring of the adenosine deaminase inhibitor coformycin (12), is a much less potent inhibitor of the enzyme but still binds to the enzyme about as tightly as the normal substrate.
摘要
4(R)-(1-羟乙基)-5-甲基-1-β-D-呋喃核糖基咪唑(10)，仅含有腺苷脱氨酶抑制剂助间型霉素(12)二氮杂环庚三烯醇环的不对称醇中心，是该酶活性低得多的抑制剂，但与酶的结合紧密程度仍与正常底物相当。
Zotero 插件