用致癌剂量的N-2-乙酰氨基芴处理大鼠期间白蛋白的合成与分泌
Synthesis and secretion of albumin in rats during treatment with a carcinogenic dose of N-2-acetylaminofluorene.
作者信息
Harson M M, Williams D J
出版信息
Br J Cancer. 1979 Nov;40(5):791-7. doi: 10.1038/bjc.1979.262.
Abstract
The chronic administration of N-2-acetylaminofluorene (N-2-AAF) to rats causes a loss of hepatic cytoplasmic RNA, particularly from the endoplasmic-membrane fractions. At the end of the complete carcinogenic dose, the level of amino-acid incorporation into proalbumin is normal, despite the loss of 35% of membrane-bound RNA. The secretion of albumin, however, is inhibited. This inhibition of secretion is apparently the result of a change in membrane flow and differentiation; transfer of nascent protein from smooth-surfaced vesicles to the Golgi apparatus is blocked. The significance of these findings is discussed.
摘要
给大鼠长期施用N-2-乙酰氨基芴（N-2-AAF）会导致肝细胞质RNA丢失，尤其是内质网膜部分的RNA。在达到完全致癌剂量末期，尽管膜结合RNA损失了35%，但氨基酸掺入前白蛋白的水平仍正常。然而，白蛋白的分泌受到抑制。这种分泌抑制显然是膜流动和分化改变的结果；新生蛋白质从光滑表面小泡向高尔基体的转运受阻。讨论了这些发现的意义。
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