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低氧性肺血管收缩与高反应性概念

Hypoxic pulmonary vasoconstriction and the concept of hyperexis.

作者信息

Fritts H W

出版信息

Bull Eur Physiopathol Respir. 1979 Sep-Oct;15(5):813-20.

PMID:508982
Abstract

Professor Cournand has a special interest in hypoxic pulmonary vasoconstriction, and Professor Richards, his colleague, had a special interest in hyperexis, two seemingly unrelated phenomena in physiology. But at the end of a series of studies on cardiac output, when younger members of the Laboratory were assessing the effect of granulomatous lung disease on the calculation of output by the Fick principle, the pulmonary vessels in the diseased lung showed behaviour consistent with hyperexis, and the individual interests of the two men unexpectedly converged.

摘要

库南德教授对低氧性肺血管收缩有着特别的兴趣,他的同事理查兹教授则对机能亢进有着特别的兴趣,这是生理学中两个看似不相关的现象。但在一系列关于心输出量的研究结束时,当实验室的年轻成员在评估肉芽肿性肺病对用菲克原理计算心输出量的影响时,患病肺中的肺血管表现出与机能亢进相符的行为,这两个人各自的兴趣意外地交汇了。

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