Parker J O, Thadani U
Bull Eur Physiopathol Respir. 1979 Sep-Oct;15(5):935-49.
Hemodynamic profiles at rest and during bicycle exercise are described in 50 normal male subjects. In nine of these, the hemodynamics at rest and during exercise in the supine position have been compared to those in the sitting position. In the supine position, the observed and derived hemodynamic parameters at rest and during exercise (mean +/- standard deviation) were: heart rate 77 +/- 11 vs 127 +/- 17 beats . min-1, brachial arterial mean pressure, 12.4 +/- 1.2 vs 15.0 +/- 1.6 kPa (93 +/- 9 vs 113 +/- 12 mmHg), pulmonary arterial mean pressure 1.9 +/- 0.5 vs 3.2 +/- 0.8 kPa (14 +/- 4 vs 24 +/- 6 mmHg), left ventricular end-diastolic pressure 1.2 +/- 0.4 vs 1.7 +/- 0.7 kPa (9 +/- 3 vs 13 +/- 5 mmHg), cardiac output 6.3 +/- 1.5 vs 12.0 +/- 3.0 1 . min-1, stroke volume 88 +/- 22 vs 95 +/- 23 cm3, and left ventricular stroke work 0.93 +/- 0.27 vs 1.26 +/- 0.34 J . beats-1. Comparison of hemodynamic data in the supine and sitting position showed that pulmonary capillary wedge pressure, left ventricular end-diastolic pressure, cardiac output, stroke volume, and left ventricular stroke work were lower and heart rate higher in the sitting position, while brachial arterial and pulmonary arterial mean pressures were similar in the two positions. During exercise, the absolute values of pulmonary capillary wedge pressure, left ventricular end-diastolic pressure and stroke volume were lower and heart rate higher in the sitting position, while cardiac output and left ventricular stroke work were similar in the two positions. Comparison of changes from rest to exercise in the supine and sitting postures revealed similar increases in heart rate, pulmonary capillary wedge pressure, left ventricular end-diastolic pressure, cardiac output, and stroke volume in the two positions.
本文描述了50名正常男性受试者静息状态和自行车运动期间的血流动力学情况。其中9名受试者，对其仰卧位静息和运动时的血流动力学与坐位时进行了比较。仰卧位时，静息和运动时观察到的及推导得出的血流动力学参数（均值±标准差）为：心率77±11次/分钟 vs 127±17次/分钟，肱动脉平均压12.4±1.2 kPa（93±9 mmHg） vs 15.0±1.6 kPa（113±12 mmHg），肺动脉平均压1.9±0.5 kPa（14±4 mmHg） vs 3.2±0.8 kPa（24±6 mmHg），左心室舒张末期压力1.2±0.4 kPa（9±3 mmHg） vs 1.7±0.7 kPa（13±5 mmHg），心输出量6.3±1.5 L/分钟 vs 12.0±3.0 L/分钟，每搏输出量88±22 cm³ vs 95±23 cm³，左心室每搏功0.93±0.27 J/次 vs 1.26±0.34 J/次。仰卧位和坐位血流动力学数据比较显示，坐位时肺毛细血管楔压、左心室舒张末期压力、心输出量、每搏输出量和左心室每搏功较低，心率较高；而肱动脉和肺动脉平均压在两种体位相似。运动期间，坐位时肺毛细血管楔压、左心室舒张末期压力和每搏输出量的绝对值较低，心率较高；而心输出量和左心室每搏功在两种体位相似。仰卧位和坐位从静息到运动的变化比较显示，两种体位中心率、肺毛细血管楔压、左心室舒张末期压力、心输出量和每搏输出量的增加相似。
