一种新型合成化合物对免疫反应的调节及肿瘤扩散的控制

Modulation of the immune response and control of tumour spread by a new synthetic compound.

作者信息

Falk R E, Makowka L, Nossal N, Falk J A, Fields J E, Asculai S S

出版信息

Br J Surg. 1979 Dec;66(12):861-3. doi: 10.1002/bjs.1800661208.

DOI:10.1002/bjs.1800661208

Abstract

A small molecular weight biofunctional polymer, NED 137, has been investigated for its anti-neoplastic effect. Through its effect on the immune system, particularly the induction of B cell differentiation to antibody producing cells, this synthetic compound can retard tumour growth and prevent the development of distant metastases. Reactivity to tumour developed following administration of the NED 137. No toxicity has been observed. The polymer NED 137 is now being tested in phase I and phase II clinical trials.

摘要

一种小分子量的生物功能聚合物NED 137已被研究其抗肿瘤作用。通过对免疫系统的作用，特别是诱导B细胞分化为抗体产生细胞，这种合成化合物可以延缓肿瘤生长并防止远处转移的发生。给予NED 137后对肿瘤产生反应。未观察到毒性。聚合物NED 137目前正在进行I期和II期临床试验。

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