脑膜炎球菌抗原（MA）：实验性肿瘤形成中的一种新型免疫刺激剂。
Menningococcal antigens (MA): a novel immune stimulant in experimental neoplasia.
作者信息
Teodorczyk-Injeyan J A, Sparkes B G, Dupuy J M, Micusan V V, Falk R E
出版信息
Cancer Immunol Immunother. 1983;15(3):217-20. doi: 10.1007/BF00199168.
An extract of the meningococcus antigens (MA) prepared from N. meningitidis was tested for an anti-tumor effect in rat and murine metastasizing tumor models. Effectiveness of MA in each model varied with dose and was manifested as significantly improved survival of the treated animals. Growth of the primary Fischer bladder carcinoma (FBCa) and metastases to lungs and lymph nodes were significantly inhibited in F344 rats treated weekly with 1 mg MA. Administration of MA at 100 micrograms per animal significantly prolonged survival of P815 mastocytoma-inoculated DBA/2 mice. Survival of C-26 colon adenocarcinoma-bearing Balb/c mice was significantly improved in animals that received weekly injections of 20 micrograms MA, without significant effect on the development of local tumor. The meningococcal antigens demonstrate strong mitogenic activity in B-cell-enriched murine spleen cultures. Thus the immunostimulatory activity of MA in experimental malignancy could involve, directly or indirectly, activation of B lymphocytes.
从脑膜炎奈瑟菌制备的脑膜炎球菌抗原提取物（MA）在大鼠和小鼠转移性肿瘤模型中进行了抗肿瘤作用测试。MA在每个模型中的有效性随剂量而变化，表现为治疗动物的存活率显著提高。每周用1mg MA治疗的F344大鼠中，原发性Fischer膀胱癌（FBCa）的生长以及肺和淋巴结转移均受到显著抑制。每只动物给予100μg MA可显著延长接种P815肥大细胞瘤的DBA/2小鼠的生存期。每周注射20μg MA的携带C-26结肠腺癌的Balb/c小鼠的生存期显著提高，对局部肿瘤的发展无显著影响。脑膜炎球菌抗原在富含B细胞的小鼠脾脏培养物中表现出强大的促有丝分裂活性。因此，MA在实验性恶性肿瘤中的免疫刺激活性可能直接或间接涉及B淋巴细胞的激活。
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